Recent targets of osteoarthritis research

Shih, Po-Cheng; Lee, Yung‐Heng; Tsou, Hsi‐Kai; Wei, James Cheng‐Chung

doi:10.1016/j.berh.2023.101851

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…Inflammatory responses are known to contribute to the development and progression of OA ( 30 ). Inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, can promote cartilage breakdown, induce synovial changes, and inhibit repair mechanisms, thereby increasing the risk of OA ( 31 ). Fourth, many jobs involving heavy physical labor often do not provide sufficient rest and recovery time for the musculoskeletal system ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study

Huang

2024

Front. Public Health

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BackgroundOsteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis. We conducted a two-sample Mendelian randomization (MR) study to estimate the causal effects of two common occupational factors—job involves heavy manual or physical work and job involves mainly walking or standing—on OA and RA in individuals of European ancestry.MethodsInstruments were chosen from genome-wide association studies (GWASs) that identified independent single nucleotide polymorphisms (SNPs) robustly linked to job involves heavy manual or physical work (N = 263,615) as well as job involves mainly walking or standing (N = 263,556). Summary statistics for OA and RA were taken from the Integrative Epidemiology Unit (IEU) GWAS database; both discovery and replication GWAS datasets were considered. The primary analysis utilized the inverse variance weighted (IVW) MR method supplemented by various sensitivity MR analyses.ResultsIn the IVW model, we found that genetically predicted job involves heavy manual or physical work was significantly associated with OA in both the discovery [odds ratio (OR) = 1.034, 95% confidence interval (CI): 1.016–1.053, P = 2.257 × 10−4] and replication (OR = 1.857, 95% CI: 1.223–2.822, P = 0.004) analyses. The causal associations were supported in diverse sensitivity analyses. MR analyses suggested no causal effect of genetically predicted job involves heavy manual or physical work on RA. Similarly, our data provided no evidence that genetically predicted job involves mainly walking or standing was related to OA and RA.ConclusionsOur MR study suggests that job involves heavy manual or physical work is a risk factor for OA. It is of utmost importance to create preventive strategies aimed at reducing its impact on OA at such work sites.

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Section: Discussionmentioning

confidence: 99%

The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study

Huang

2024

Front. Public Health

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Targeting Macrophages via Ultrasonic Contrast Microspheres for Monitoring and Treatment of Knee Synovitis

Han,

Guan,

Ding

et al. 2024

Adv Funct Materials

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The malignant cycle of synovitis considerably impacts the progression of osteoarthritis (OA). Therefore, the precise localization of synovitis, targeted disruption of the inflammatory cycle, and real‐time monitoring of its dynamics are crucial for the effective diagnosis and management of OA. Here, porous HAMA/GelMA microspheres are synthesized using microfluidic technology. Interleukin‐10 (IL‐10) nanobubbles, prepared via double emulsification, are grafted with folic acid (FA) via an amide reaction and subsequently impregnated and adsorbed onto the microspheres, thereby constructing an ultrasonic contrast microsphere system. This system facilitates not only ultrasonic imaging for accurate localization of synovitis but also the targeted and controlled delivery of IL‐10 under ultrasound conditions. In vitro, under ultrasound intensities of 0, 0.5, and 1.5 W, the system effectively releases IL‐10 at the rates of 19.95%, 30.95%, and 40.67%, respectively. In vivo, the biodegradability of the system facilitates real‐time tracking and monitoring of synovitis for at least 14 days. In summary, ultrasonic contrast microspheres enable precise localization and real‐time monitoring of synovitis. Under ultrasound conditions, these microspheres enable targeted and controlled drug delivery, effectively disrupting vicious inflammatory cycles. This strategy pioneers new pathways for the management and precise treatment of OA.

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Recent targets of osteoarthritis research

Cited by 2 publications

References 86 publications

The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study

The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study

Targeting Macrophages via Ultrasonic Contrast Microspheres for Monitoring and Treatment of Knee Synovitis

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