Recent Tanning Bed Use

“…Consistent with this, nevi at exposed sites progressed to severe dysplasia and to melanoma following a series of sunbed exposures that induced tanning (Tucker M., unpublished data and ref. 49), arguing against the idea that sunbed-induced tanning offers protection against skin cancer.…”

Section: Discussionmentioning

confidence: 99%

Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

et al. 2012

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Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.

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“…Within the setting of families at high risk of developing melanoma, several pigmented lesions can change during a limited period. 29,30 Initial staging of these individuals for metastatic disease could also contribute to the increased risk within the first year for cancers of the thyroid, salivary gland, and kidney, as well as NHL and chronic lymphocytic leukemia. The decline in risk of melanoma over time could also reflect decreasing risk of melanoma owing to changed behavior, such as decreased sun exposure and enhanced sun-protective behaviors after an initial diagnosis of melanoma.…”

Section: Commentmentioning

confidence: 99%