Recent synthetic ion channels and pores

Matile, Stefan; Som, Abhigyan; Sordé, Nathalie

doi:10.1016/j.tet.2004.05.052

Cited by 211 publications

(159 citation statements)

References 226 publications

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“…Apart from a central role in oligonucleotide chemistry and biology (18), cofacial p-stack architecture contributes very little to electron transfer in biological (1-3) and synthetic (4-7) photosystems, not to speak of the structure of biological or synthetic ion channels or pores (19). Recently, we have demonstrated that the rational design of refined transmembrane p-stack architecture is feasible with the use of rigid-rod molecules as preorganizing scaffolds (20,21).…”

mentioning

confidence: 99%

Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers

Bhosale

Sisson

Talukdar

et al. 2006

Science

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416

372

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Rigid p -octiphenyl rods were used to create helical tetrameric π-stacks of blue, red-fluorescent naphthalene diimides that can span lipid bilayer membranes. In lipid vesicles containing quinone as electron acceptors and surrounded by ethylenediaminetetraacetic acid as hole acceptors, transmembrane proton gradients arose through quinone reduction upon excitation with visible light. Quantitative ultrafast and relatively long-lived charge separation was confirmed as the origin of photosynthetic activity by femtosecond fluorescence and transient absorption spectroscopy. Supramolecular self-organization was essential in that photoactivity was lost upon rod shortening (from p -octiphenyl to biphenyl) and chromophore expansion (from naphthalene diimide to perylene diimide). Ligand intercalation transformed the photoactive scaffolds into ion channels.

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mentioning

confidence: 99%

Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers

Bhosale

Sisson

Talukdar

et al. 2006

Science

Self Cite

416

372

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“…4 The axial trajectories of three Na + ions from a 3M solution and their interactions in the channel. Their mutual interactions are observable and are discussed in the text.…”

Section: Diffusion In Advanced Materialsmentioning

confidence: 99%

Molecular Dynamics of the Transport of Ions in a Synthetic Channel

Morton-Blake¹

2014

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Abstract. Molecular dynamics investigations of ions in certain non-bulk media predict that they are capable of significantly greater mobilities than when in the liquid state. The entries of Li + , Na + , and K + ions from electrolyte media into proposed synthetic channels consisting of fourteen 15-crownether-5 (CE) rings bonded in stacked conformations are described and their subsequent dynamics in the channel discussed. The importance of channel flexibility is established by investigating two CE channels that are structurally similar but vary in the rigidity with which their rings are connected. The dynamics of cation channel migrants are simulated across a bilayer membrane between two bulk aqueous salt solutions and also when the channel floats freely in an aqueous medium. Various features of ion behaviour are investigated in the presence, and in the absence, of an electric field applied along the channel axis. The novel oscillatory behaviour of the ions in the channel is investigated, together with the possibility of their exits into the liquid medium. The frictional forces opposing the ion trajectories are calculated, found to be ~10 nN and attempts to formulate frictional laws for nanoscale systems are discussed.

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“…For an organic chemist entering the field without BLMs, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] LUVs provide a user friendly and, according to the comparative studies discussed below, valid alternative. Among several possible methods to determine anion/cation selectivity of synthetic ion channels in vesicles, the HPTS assay worked best in our hands (Fig.…”

Section: Determination Of Anion/cation Selectivity In Vesicles For Symentioning

confidence: 99%

“…Ironically, it is the experimental evidence for the existence of ion channels as such (rather than the presence of alternative modes of transport) that remains most difficult to obtain in vesicles. 18 In the following, we first summarize classical methods to determine the ion selectivity of synthetic channels and pores in BLMs. Shifting attention from BLMs to LUVs, we then describe our favorite methods to determine anion/cation selectivity and selectivity sequences, provide examples how ion selectivity can be expressed in different assays and introduce the use of additives to identify proton selectivity, potassium selectivity, and weak anion/cation selectivity.…”

Section: Introductionmentioning

confidence: 99%

The determination of the ion selectivity of synthetic ion channels and pores in vesicles

Sakai

Matile

2006

J of Physical Organic Chem

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Organic chemists entering the field of synthetic ion channels and pores are often restricted to the characterization of their creation by fluorescence kinetics in vesicles and do not have access to conductance experiments in planar bilayer membranes. This limitation excludes the application of methods to evaluate key characteristics such as ion selectivity or voltage gating that are routine in the membrane biophysics community.

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Recent synthetic ion channels and pores

Cited by 211 publications

References 226 publications

Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers

Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers

Molecular Dynamics of the Transport of Ions in a Synthetic Channel

The determination of the ion selectivity of synthetic ion channels and pores in vesicles

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