Recent synthetic and medicinal perspectives of tryptanthrin

Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune

“…In previous studies, I.indigotica was demonstrated to have various pharmacologically active compounds in crude herbs (Li et al, 2015;Meng et al, 2017;Yang et al, 2014). Compounds such as indican, quinazolinone, indirubin (INR), tryptanthrin, glucosinolate and their derivatives extract from I. indogotica are identified to have antiviral, anti-inflammatory and anticancer effects Kaur et al, 2017;Shi et al, 2012). INR has a significant effect on chronic myelocytic leukemia (CML), and a possible mechanism has been investigated in animal studies (Mohan et al, 2018).…”

A Brønsted Acid‐Catalyzed Michael Addition/Cyclization Sequence for the Diastereoselective Assembly of Chroman‐Bridged Polycyclic Isoindolinones

“…Polycyclic isoindolinones are important structural units which are commonly found in natural products and pharmaceuticals and exhibit a wide range of bioactivities ( Figure 1). [1] For instance, compound 1 was used as HIV-1 reverse transcriptase inhibitor. [1a] Tryptanthrin, first isolated from the culture of yeast Candida lipolytica, showed antifungal activity and antitumor activity.…”

Palladium Catalyzed Cross‐Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2‐b]quinazolinone

“…[24] Other oxidants such as K 2 S 2 O 8 , H 2 O 2 , AgOAc and Cu(OAc) 2 did not promote the desired reaction (Table 1, entries 7- 10). Other catalysts including Cu(OAc) 2 , PdCl 2 , Ru(p-cymene)Cl 2 , Ru(COD)Cl 2 , and Co(OAc) 2 were also ineffective under the present conditions (Table 1, entries [15][16][17][18][19]. Additionally, the increase in the mount of TBHP to four equivalents has resulted in a yield increase of up to 52 % (Table 1, entry 12).…”

“…[11] The pyrrolo[2,1-b]quinazolinone structural motif is gaining prominence in medicinal and organic chemistry. [13][14][15][16][17] In spite of their biological importance, the number of studies on the synthesis of these fused heterocyclic structures have rarely been reported. [13][14][15][16][17] In spite of their biological importance, the number of studies on the synthesis of these fused heterocyclic structures have rarely been reported.…”