Recent syntheses of steroid derivatives using the CuAAC “click” reaction

Abstract

The introduction of heterocycles into steroids is often at the origin of a modification of their physiological activity and thus allows the formation of new biologically interesting molecules. Recent advances in the field of steroid synthesis using the copper-catalyzed azide-alkyne cycloaddition (CuAAC) are presented here. Compounds exhibiting known biological activities are also reported in this review. This approach holds great promise and allows us to consider preparing new, highly functionalized complex molecules using the CuAAC "click" reaction.

Steroidal lactams: a review

“…Research into steroid total synthesis continues to this day. [35][36][37][38] The introduction of heteroatom or replacement of one or more carbon atoms in a steroidal molecule by a heteroatom affects the chemical properties of that particular steroid and often results in alterations of its biological activities, which sometimes may be useful. Azasteroids especially express numerous biological activities.…”

A short review on selena and tellurasteroids

“…Research into steroid total synthesis continues to this day. [28][29][30][31] The fact that the introduction of a heteroatom in steroid structures can cause extensive changes in biological activity has long intrigued medicinal chemists. Naturally occurring steroid nuclei have been modified in several ways to recognize the structural and stereochemical features required for the display of specific, selective physiological activity and for finding more active compounds, free from undesirable or harmful side effects.…”