Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism

Antiaging Effect of 4-N-Furfurylcytosine in Yeast Model Manifests through Enhancement of Mitochondrial Activity and ROS Reduction

“…Since the aging process is highly related to mitochondria and changes in metabolism, we investigated the effect of FC on the activity of mitochondria. Previous reports on aging clearly show that decreased respiration leads to an increase in the level of ROS and reduces lifespan [62,63], and most antiaging compounds act by preventing the loss of mitochondrial function and accumulation of ROS [55]. Additionally, both rapamycin and CR increase the rate of oxygen consumption by yeast cells [61].…”

“…Another well-described antiaging intervention, calorie restriction (CR), also improves viability in a variety of species, and its action involves the partial inhibition of the TOR pathway [35,53]. Despite certain similarities, the exact mechanism of action of CR and rapamycin differs [54,55], but it is known that metabolism changes are a key factor in the aging process.…”

“…Apart from rapamycin and CR, resveratrol, metformin, or spermidine, which display promising activity in humans, have been tested in yeast [17]. It should be mentioned that, due to their antioxidant properties, flavonoids, a profound group of compounds, have been proven to have a positive effect on the aging of yeast [55].…”

Evaluation of In Situ Antiaging Activity in Saccharomyces cerevisiae BY611 Yeast Cells Treated with Polyalthia longifolia Leaf Methanolic Extract (PLME) Using Different Microscopic Approaches: A Morphology-Based Evaluation

“…S. cerevisiae yeast is a significant antiaging study model, which has evolutionarily conserved genes crosswise species, including human genes (Longo & Fabrizio, 2002; Lasserre et al, 2015). S. cerevisiae yeast is considered a valuable initial point model for antiaging study due to the long human lifespan and unknown adverse reactions that might be shown by the prospective antiaging agent being tested (Yalcin & Lee, 2019). In this study, the lifespan of S. cerevisiae yeast was evaluated using RLS of the cells, which determined the number of times a mother yeast cell can create a new daughter yeast cell (Yalcin & Lee, 2019).…”

“…S. cerevisiae yeast is considered a valuable initial point model for antiaging study due to the long human lifespan and unknown adverse reactions that might be shown by the prospective antiaging agent being tested (Yalcin & Lee, 2019). In this study, the lifespan of S. cerevisiae yeast was evaluated using RLS of the cells, which determined the number of times a mother yeast cell can create a new daughter yeast cell (Yalcin & Lee, 2019). Furthermore, this study did not use the positive control group since this is the first study to evaluate the antiaging activity and will use such a control group in future detail studies.…”