Recent studies of the hematopoietic microenvironment in long-term bone marrow cultures

Greenberger, Joel S.; Fitzgerald, Thomas J.; Anklesaria, Pervin

doi:10.1007/bf02918147

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…Although long considered a cell autonomous disorder, recent data suggest that the microenvironment contributes to the pathophysiology of MDS. [32][33][34][35][36] Stroma cells are one of several key components of the microenvironment. We have shown, for example, that the co-injection of human marrow stroma cells with hematopoietic MDS cells into mice enabled propagation of the MDS clone, suggesting that stroma cells may contribute to the survival of MDS precursors.…”

Section: Discussionmentioning

confidence: 99%

The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes

Marcondes

Gooley

et al. 2010

Blood

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Section: Discussionmentioning

confidence: 99%

The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes

Marcondes

Gooley

et al. 2010

Blood

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“…MDS are not only characterized by peripheral cytopenias and the presence of clonal blast cells in the BM, but also by alterations in the BM microenvironment. In particular, the BM microenvironment is severely disturbed in MDS and AML and supposedly contributes to disease evolution and progression [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Every stage of disease initiation, propagation, and progression from early-stage (low-risk) MDS to late-stage (high-risk) MDS and AML may be defined by specific events relevant to the communication between the dysplastic/leukemic clone and the pathologically altered microenvironment (reviewed, e.g., in [ 16 ]).…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Pleyer

Valent

Greil

2016

IJMS

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Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution and propagation of MDS. We here present an overview of the role of MSCs in the pathogenesis of MDS, with emphasis on cellular interactions in the BM microenvironment and related stem cell niche concepts. MSCs have potent immunomodulatory capacities and communicate with diverse immune cells, but also interact with various other cellular components of the microenvironment as well as with normal and leukemic stem and progenitor cells. Moreover, compared to normal MSCs, MSCs in MDS and AML often exhibit altered gene expression profiles, an aberrant phenotype, and abnormal functional properties. These alterations supposedly contribute to the “reprogramming” of the stem cell niche into a disease-permissive microenvironment where an altered immune system, abnormal stem cell niche interactions, and an impaired growth control lead to disease progression. The current article also reviews molecular targets that play a role in such cellular interactions and possibilities to interfere with abnormal stem cell niche interactions by using specific targeted drugs.

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“…In conjunction, stromal cells create a microenvironment in which hematopoiesis occurs. The role of these stromal elements in hematopoiesis is critical and hematopoietic development in vivo and in long‐term cultures of hematopoietic progenitors depends on the presence of an appropriate stroma (Dexter et al, 1977; Johnson and Dorshkind, 1986; Greenberger et al, 1989; Testa and Dexter, 1991; Deryugina et al, 1994; Blazsek et al, 2000). The advent of stromal clonal cell lines helped in the elucidation of the signals derived from the stromal cells that affect hematopoiesis.…”

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confidence: 99%

Electrocardiographic QRS Duration Reflects Right Ventricular Remodeling in Patients Undergoing Corrective Surgery for Isolated Tricuspid Regurgitation: A Comparative Study with Cardiac Magnetic Resonance Imaging

Seo

Park

Kim

et al. 2012

Clinical Cardiology

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Background:The role of electrocardiogram (ECG) is unclear for the longitudinal follow-up of patients who undergo corrective surgery for isolated severe tricuspid regurgitation (TR). Hypothesis: This study sought to investigate the usefulness of changes in QRS duration of ECG after TR surgery in predicting right ventricular (RV) reverse remodeling as determined by cardiac magnetic resonance imaging (CMR). Methods: We enrolled 30 consecutive TR patients (27 women, aged 57.8 ± 9.6 years) who had undergone prior left-sided valve surgery. A computer-assisted analysis was performed for objective calculation of QRS duration before and after surgery. Results: At a median CMR follow-up of 27.5 months postsurgery, QRS duration was cut by 14.6%, from 110.4 ± 14.6 msec to 96.9 ± 11.9 msec (P < 0.001), while CMR showed a decrease in RV end-diastolic volume index (RV-EDVI) from 179.5 ± 59.7 to 119.1 ± 30.4 mL/m 2 (P < 0.001). QRS duration correlated significantly with RV-EDVI and RV end-systolic volume index (r = 0.65, P < 0.001 and r = 0.53, P < 0.001, respectively), and a percent change in QRS duration was significantly correlated with a percent change in RV-EDVI (r = 0.40, P = 0.03). When significant RV reverse remodeling was defined as a reduction in RV-EDVI ≥20% following TR surgery, the sensitivity and specificity for significant RV reverse remodeling were 75% and 78%, respectively, with a 9% reduction in QRS duration (P = 0.01, area underneath the receiver operator curve [AUC] = 0.81). Conclusions:The extent of changes in postoperative QRS duration can be used as a useful, inexpensive, and simple index reflecting the occurrence of significant RV reverse remodeling in patients undergoing corrective TR surgery.

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Recent studies of the hematopoietic microenvironment in long-term bone marrow cultures

Cited by 10 publications

References 33 publications

The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes

The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Electrocardiographic QRS Duration Reflects Right Ventricular Remodeling in Patients Undergoing Corrective Surgery for Isolated Tricuspid Regurgitation: A Comparative Study with Cardiac Magnetic Resonance Imaging

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