“Recent Studies in Histaminase”

Kapeller‐Adler, R.; Mcfarlane, H. A. F.

doi:10.1177/036985646100100411

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1962

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“…The secondary amines were without significant inhibitory action on the oxidation of cadaverine by the pig kidney oxidase. There is some doubt whether the enzyme that inactivates histamine is identical with diamine oxidase (see Kapeller-Adler & MacFarlane, 1962). However, if they are distinct, they must be closely related.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of the Response to Histamine by Picolylamines

Blaschko

Kurzepa

1962

British Journal of Pharmacology and Chemotherapy

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The response of the isolated ileum of the guinea-pig to histamine is potentiated in the presence of 2-, 3-or 4-picolylamine. These compounds have been found to inhibit the histaminase and/or " diamine oxidase" of pig kidney. The three corresponding picolylmethylamines did not potentiate the response of the ileum to histamine; they were without significant affinity for the pig kidney oxidase. It is suggested that the potentiating action of the three primary amines is due to their inhibitory action on histaminase. The responses of the ileum to acetylcholine and 5-hydroxytryptamine were not potentiated.

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Section: Discussionmentioning

confidence: 99%