Recent Strategies for Efficient Synthesis and Biological Activities of Coumarin-Chalcone Derivatives

Abstract

Coumarins and chalcones are potential pharmacological and biologically active molecules obtained from natural source. Coumarins have predominant pharmacological activities such as antidiabetic, antitumor, and anti-inflammatory activity. Chalcones are also one of the naturally occurring pharmacologically vital molecules with different activities such as anti-inflammatory, antitumor, antimicrobial, and antimalarial activity. Literature reveals that a huge number of coumarinyl chalcone derivatives have various pharmacological activities. Coumarinyl chalcone derivatives gained more prominence due to their significant biological activities. This work explains the current information about synthesis techniques, pharmacological importance, and clinical applications of coumarinyl chalcone derivatives.

EXPLORING THE THERAPEUTIC POTENTIAL OF AM114: A BORONIC CHALCONE DERIVATIVE INDUCE APOPTOSIS AND SUPPRESS PROINFLAMMATORY CYTOKINES AND CHEMOKINES IN INTERLEUKIN-1β STIMULATED HUMAN THP-1 DERIVED MACROPHAGES

“…Chalcones are a class of organic compounds known for their diverse pharmacological properties, including anticancer, antimicrobial, anti-inflammatory, and antioxidant properties. A recent study explores the coumarin-chalcone derivative's efficient synthesis and biological activity [11]. The proteasome has a central role in regulating macrophage function by inhibiting the proteasome with several naturally occurring inhibitors [12].…”