Recent Scenario for the Synthesis of Benzimidazole Moiety(2020–2022)

Abstract

study focuses on synthesis of benzimidazole derivatives by numerous homogeneous catalysts related from s-block, pblock, transition metal, inner transition metal and environmentally benign synthetic approaches, via heterogeneous catalyst in metal-free conditions. Benzimidazole has several applications in pharmaceuticals, agrochemicals and fine chemicals. Its scaffolds are omnipresent in several bioactive natural products and pharmaceutically important compounds. This review highlights synthetic approaches and studies of benzimidazole reported from the year 2020 onwards.

Synthesis of 2-Methylbenzimidazole in Continuous Flow: Mechanism of Cu–Pd/(K)γ-Al2O3-Catalyzed Deactivation and Regeneration

“…Benzimidazole is a heteroaromatic organic compound commonly known as 1H-benzimidazole, benz­(e)­imidazole, or 1,3-benzothiazole. The compound’s planarity results from the fusion of a benzene ring and a five-membered imidazole ring, which contains two nitrogen atoms. , The π-electrons from both rings interact to form stable electron-delocalized systems through a double-bond connection. This intricate molecular arrangement gives rise to a distinctive chemical structure accompanied by exceptional electronic effects.…”