Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome

Yan, Juan; Chi, Jo-Feng; LoMonaco, Kaelene; A.C.M., Boon,; Gu, Haiwei

doi:10.1016/j.trac.2023.117155

Cited by 7 publications

(3 citation statements)

References 294 publications

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“…Activation directly activates the vagus nerve, which connects the enteric nervous system to the CNS. Moreover, a multitude of metabolites generated by the microbiome find their way into the bloodstream via the intestinal barrier [59,60]. Transmitting across the BBB, these metabolites can modulate neurological processes.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, these amounts correlate with the health outcomes of the offspring. In addition to altered metagenome, metabolome, and/or immune responses that may impact host processes, a perturbed microbiome may subsequently influence health through aberrant metabolism of dietary intake [59]. Thus, it is crucial for the development of the progeny that the mother maintains a consortium of health-promoting microorganisms.…”

Section: Bibliometric Analysismentioning

confidence: 99%

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The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Tzitiridou-Chatzopoulou,

Kountouras,

Zournatzidou

2024

Children

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Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period from birth to three years old may yield the greatest benefits. Investigating the substantial link between the gut and brain during this crucial developmental phase raises fundamental issues about the role of microorganisms in human health and brain development. This underscores the importance of focusing on the prevention rather than the treatment of neurodevelopmental and neuropsychiatric disorders. The present review examines the gut microbiota from birth to age 3, with a particular focus on its potential relationship with neurodevelopment. This review emphasizes the immunological mechanisms underlying this relationship. Additionally, the study investigates the impact of the microbiome on cognitive development and neurobehavioral issues such as anxiety and autism. Importantly, it highlights the need to integrate mechanistic studies of animal models with epidemiological research across diverse cultures to better understand the role of a healthy microbiome in early life and the implications of dysbiosis. Furthermore, this review summarizes factors contributing to the transmission of gut microbiome-targeted therapies and their effects on neurodevelopment. Recent studies on environmental toxins known to impact neurodevelopment are also reviewed, exploring whether the microbiota may mitigate or modulate these effects.

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Section: Discussionmentioning

confidence: 99%

Section: Bibliometric Analysismentioning

confidence: 99%

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Tzitiridou-Chatzopoulou,

Kountouras,

Zournatzidou

2024

Children

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show abstract

“…The untargeted LC-MS metabolomic method was adapted from previously published methods. [88][89][90][91][92] In summary, each sample was injected twice (10 μL for negative ionization mode, 4 μL for positive ionization mode) onto an XBridge BEH Amide column (150 x 2.1 mm, 2.5 µm particle size, Waters) maintained at 40 . Samples were maintained in an autosampler at 4 .…”

Section: Untargeted Lc-ms Analysis Of Stool Metabolomementioning

confidence: 99%

Baseline gut microbiome and metabolites are correlated with alcohol consumption in a zonisamide clinical trial of heavy drinking alcoholic civilians

Dedon,

Yuan,

Chi

et al. 2024

Preprint

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Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota and their associated metabolites in both animal and human studies. However, the involvement of the gut microbiome in alcohol consumption of individuals with AUD undergoing treatment remains unclear. To address this, stool samples (n=48) were collected at screening (baseline) and trial completion from a single site of a multi-site double-blind, placebo-controlled trial of Zonisamide in individuals with AUD. Alcohol consumption, gamma-glutamyl transferase (GGT), and phosphatidylethanol (PEth)levels were measured both at baseline and endpoint of 16-week trial period. Fecal microbiome was analyzedvia16S rRNA sequencing and metabolomeviauntargeted LC-MS. Both sex (p = 0.003) and psychotropic medication usage (p = 0.025) are associated with baseline microbiome composition. The relative abundance of 12 genera at baseline was correlated with percent drinking reduction, baseline and endpoint alcohol consumption, and changes in GGT and PeTH over the course of treatment (p.adj < 0.05). Overall microbiome community structure at baseline differed between high and low responders (67-100% and 0-33% drinking reduction, respectively; p = 0.03). A positive relationship between baseline fecal GABA levels and percent drinking reduction (R=0.43, p < 0.05) was identified by microbiome function prediction and confirmed by ELISA and metabolomics. Predicted microbiome function and metabolomics analysis have found that tryptophan metabolic pathways are over-represented in low responders. These findings highlight importance of baseline microbiome and metabolites in alcohol consumption in AUD patients undergoing zonisamide treatment.

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Guardians of the Gut: Harnessing the Power of Probiotic Microbiota and Their Exopolysaccharides to Mitigate Heavy Metal Toxicity in Human for Better Health

Dahiya,

Kumari,

Behl

et al. 2024

Probiotics & Antimicro. Prot.

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Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome

Cited by 7 publications

References 294 publications

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Baseline gut microbiome and metabolites are correlated with alcohol consumption in a zonisamide clinical trial of heavy drinking alcoholic civilians

Guardians of the Gut: Harnessing the Power of Probiotic Microbiota and Their Exopolysaccharides to Mitigate Heavy Metal Toxicity in Human for Better Health

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