Recent review of the effect of nanomaterials on stem cells

Xu, Zhou; Yuan, Long; Wu, Chengzhou; Chen, Cheng; Luo, Gaoxing; Deng, Jun; Mao, Zhengwei

doi:10.1039/c8ra02424c

Cited by 37 publications

(26 citation statements)

References 180 publications

(264 reference statements)

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“…Therefore, to achieve success in the application of NSC-mediated therapy and to overcome the obstacles of using stem cells in clinical scale, these issues must be resolved. The unique properties of nanomaterials such as high surface-to-volume ratio (S/V), high surface energy, distinctive mechanical, thermal, electrical, magnetic, and optical behaviors make them appropriate to address barriers in neural stem-cell therapy [32,46]. Improvement of the efficiency of stem-cell culture system through nanomaterials can be carried out by various methods such as direct addition of NMs to the culture media, coating of culture container and also conjugation of NMs with specific scaffold for 3D culture systems.…”

Section: Application Of Nanotechnology In Stem-cell Therapymentioning

confidence: 99%

“…By recently developed synthetic and modification methodologies, engineered NPs can be designed to desired sizes, shapes, compositions and properties. Moreover, the combination of bioorganic/bioinorganic techniques with chemistry facilitated fabrication of multiple functionalized NPs as nanoengineered compounds [46].…”

Section: Application Of Nanotechnology In Stem-cell Therapymentioning

confidence: 99%

“…The application of biomaterials, including nanoparticles will be a benefit to the regenerative medicine over the use of existing media that facilitates cell growth and differentiation into specific lineages. Based on size-dependent cellular uptake rates, NPs in size range of 20-70 nm have shown the best efficiency for stem-cell differentiation [46,54]. Using tissue engineering technology, stem cells have the potential to produce patient-specific tissues or cells without concern of immune rejection.…”

Section: Nanomedicine For Modulation Of Neural Stem-cell Differentiationmentioning

confidence: 99%

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Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

et al. 2020

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In addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. In recent years, application of stem cells has been widely advanced due to their potential of self-renewal and differentiation to different cell types which make them suitable candidates for cell therapy. In particular, this approach offers great opportunities for the treatment of neurodegenerative disorders. However, some major issues related to stem-cell therapy, including their tumorigenicity, viability, safety, metastases, uncontrolled differentiation and possible immune response have limited their application in clinical scales. To address these challenges, a combination of stem-cell therapy with nanotechnology can be a solution. Nanotechnology has the potential of improvement of stem-cell therapy by providing ideal substrates for large scale proliferation of stem cells. Application of nanomaterial in stem-cell culture will be also beneficial to modulation of stem-cell differentiation using nanomedicines. Nanodelivery of functional compounds can enhance the efficiency of neuron therapy by stem cells and development of nanobased techniques for real-time, accurate and long-lasting imaging of stem-cell cycle processes. However, these novel techniques need to be investigated to optimize their efficiency in treatment of neurologic diseases.

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Section: Application Of Nanotechnology In Stem-cell Therapymentioning

confidence: 99%

Section: Application Of Nanotechnology In Stem-cell Therapymentioning

confidence: 99%

Section: Nanomedicine For Modulation Of Neural Stem-cell Differentiationmentioning

confidence: 99%

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Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

et al. 2020

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“…Antibiotics loaded with adipose-derived, bone marrow-derived or mesenchymal SCs showed effective antibacterial and antimicrobial activities against drug-resistant infections in the cases of cancer, cardiac complications, etc. [ 50 ] Use of silver nanoparticles altered the embryonic SC structure and displayed antimicrobial effect due to the overproduction of Reactive Oxygen Species (ROS) [ 51 ]. SC-based nanoparticles inhibit the replication of viruses by inactivating their attachment to the host cells.…”

Section: Introductionmentioning

confidence: 99%

Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19

Desai

Shende

2020

Stem Cell Rev and Rep

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A potential ability of stem cells (SCs) is to regenerate and repair tissues in the human body by providing great prospects for therapeutic applications in the field of medicine. Currently, SC therapy is used in various conditions like diabetes, neurodegenerative disorders, etc. but faces some limitations like patient biocompatibility and chances of cross-infection. SCs are further modulated with nanoconjugates to overcome such challenges and will offer an advantage in the treatment of COVID-19. This pandemic requires design and development of proper treatment to save the life of human beings. Advancements in SC-based nanoconjugated therapy will open new avenues and create a significant impact in the development of futuristic nanomedicine. It may also emerge as a potential therapy for the management of infection in patients suffering from SARS-CoV-2 and related diseases such as pneumonia and virus-induced lung injuries. Graphical abstract Mechanisms of stem cell-based nanoconjugates for inhibition of replication of corona virus.

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“…The vast scientific interest in the application of nanomaterials in stem cells is attributed to their easy preparation methods, biocompatibility, unique physical and chemical properties, and their efficient interaction with biomolecules. The applications of nanomaterials in stem cell tracking and therapy have been highlighted by various previous reports [ 8 , 9 , 10 ], and further studies on the relationship between nanomaterials and stem cell differentiation are needed.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

2018

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Nanotechnology has a wide range of medical and industrial applications. The impact of metallic nanoparticles (NPs) on the proliferation and differentiation of normal, cancer, and stem cells is well-studied. The preparation of NPs, along with their physicochemical properties, is related to their biological function. Interestingly, various mechanisms are implicated in metallic NP-induced cellular proliferation and differentiation, such as modulation of signaling pathways, generation of reactive oxygen species, and regulation of various transcription factors. In this review, we will shed light on the biomedical application of metallic NPs and the interaction between NPs and the cellular components. The in vitro and in vivo influence of metallic NPs on stem cell differentiation and proliferation, as well as the mechanisms behind potential toxicity, will be explored. A better understanding of the limitations related to the application of metallic NPs on stem cell proliferation and differentiation will afford clues for optimal design and preparation of metallic NPs for the modulation of stem cell functions and for clinical application in regenerative medicine.

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Recent review of the effect of nanomaterials on stem cells

Abstract: In this review, the interactions between nanomaterials and stem cells, and their associated possible mechanisms are systematically discussed.

Cited by 37 publications

References 180 publications

Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

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