Recent respiratory infection and risk of venous thromboembolism: case-control study through a general practice database

Clayton, Tim; Gaskin, M.; Meade, T W

doi:10.1093/ije/dyr012

Cited by 101 publications

(114 citation statements)

References 15 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Well-documented VTE risk factors include age, cancer, obesity, pregnancy, hormone therapy, hospital admission, long-haul flight, hip fracture and factor V Leiden mutation [3,5,[7][8][9][10][11][12], but half of VTE cases occur unassociated with a conventional risk factor [3]. Infection and inflammation are thought to account for a significant proportion of VTE cases [3,[13][14][15][16][17][18][19][20]]. …”

Section: Introductionmentioning

confidence: 99%

Increased risk of venous thromboembolism within the first year after Staphylococcus aureus bacteraemia: a nationwide observational matched cohort study

et al. 2013

View full text Add to dashboard Cite

Objectives. Recent evidence suggests that there is an association between infection and venous thromboembolism (VTE). Here, we examined the risk of VTE after Staphylococcus aureus bacteraemia (SAB) compared to the risk in control subjects.Design and setting. Register-based nationwide observational cohort study of hospitalized patients and matched control subjects from the general population in Denmark between 1995 and 2008.Results. Amongst 15 669 SAB cases and 156 690 controls, 182 and 511, respectively, experienced VTE within 1 year. The overall incidence rate (IR) of VTE amongst cases was highest within the first 30 days [IR of deep vein thrombosis (DVT), 39.3 (95% confidence interval (CI) 28.9-53.4)/1000 person-years (PYs); IR of pulmonary embolism (PE), 16.3 (95% CI 10.1-26.2)/1000 PYs]. IRs of DVT were particularly increased amongst cases with a previous diagnosis of VTE, communityacquired infection, a history of injection drug use and in younger age groups. The overall hazard ratio of VTE for cases compared to controls declined from 15.6 (95% CI 10.3-23.5) in the first 30 days after SAB to 4.5 (95% CI 3.2-6.2) from 181 to 365 days after infection. The increased risk of VTE amongst SAB patients persisted after excluding cases with identified VTE risk factors.Conclusions. There was a particularly high risk of VTE during the first month following an episode of SAB. The risk declined over time, but remained at a threefold increased level compared to control subjects, suggesting that there are shared risk factors for SAB and VTE. Patients with SAB and welldocumented risk factors for VTE may benefit from thromboprophylaxis.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased risk of venous thromboembolism within the first year after Staphylococcus aureus bacteraemia: a nationwide observational matched cohort study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In an epidemiological study, Clayton et al, emphasized a strong association between recent respiratory infections and VTE, noticed an increased risk for DVT in the month following infection and for PE in 3 months following infection, both persisting up to a year [4].…”

Section: Discussionmentioning

confidence: 99%

Secondary prevention of systemic arterial and recurrent venous thromboembolic events, through extended time anticoagulation with apixaban, in an elderly patient with multiple comorbidities

Anghelescu

2016

Int Arch Med

View full text Add to dashboard Cite

The clinical case illustrates the daily practice with an individualized, adjusted thromboprophylactic dose of apixaban (2.5 mg twice-daily, follow-up for 20 months), mandatory indicated as a continuous therapy for secondary prevention of systemic arterial embolism and recurrent venous thromboembolic events, in an elderly obese patient, associating multiple pathological conditions (chronically anticoagulated for non valvular atrial fibrillation and stroke sequelae, multiple metabolic comorbidities such as type 2 diabetes mellitus, moderate renal insufficiency, hyperuricemia), who submitted a severe "unprovoked" phlegmasia alba dolens in the sound (left) lower limb, a decade after a (most possible) iatrogenic deep vein thrombosis at the paralyzed (right) limb.Thromboprophylaxis for an extended time, without any medical complications (neither systemic or venous thrombotic events, nor hemorrhagic ones) confirmed the product`s efficacy and safety profile. Physiopathological considerations and essential pharmacological considerations were discussed, focused on the individualized safe therapeutic approach.

show abstract

“…Despite this percentage is much greater compared to the most recently published studies on topic, 10,11,14,17 this finding is not completely surprising, since than in the recent years many literature reports have focused on link between infectious diseases, inflammation and thrombosis. 35,36 Further investigations are warranted to better define the role of infectious diseases as risk factors for PE. Immobility remains one of the most frequent risk factors for VTE, especially in elderly patients and our study confirms it in agreement with literature.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and clinical management of acute pulmonary embolism in real world: findings from TUSCAN-PE Study

Masotti

Pieralli

Panigada³

et al. 2014

Ital J Med

View full text Add to dashboard Cite

Acute pulmonary embolism (PE) remains one of the leading causes of mortality and morbidity in cardiovascular setting. Despite much information about clinical aspects and recommendations or clinical guidelines is available from literature, few data exist about the management of PE in real world of internal medicine scenario. Therefore the aim of the present study was to report on characteristics and management of PE patients admitted in this setting. TUSCAN-PE study was a multicenter, observational, retrospective, cohort study aimed to analyze data of PE patients admitted in Internal Medicine wards of Tuscany. Each center was invited to submit anonymously data of at least ten patients consecutively discharged for acute PE in 2012. Data were referred to demographic, clinical, instrumental, prognostic and therapeutic characteristics. A total of 452 patients from 28 Tuscan centers (60.2% F), with mean age 76.01±12.34 years, were enrolled. A total of 87% of patients was admitted from Emergency Department, but only 65.2% of patients with diagnosis of PE. Around one third of diagnoses of PE was performed by internists. In 14.8% of diagnoses was incidental. In 86% of patients, diagnosis was performed by computer tomography pulmonary angiography. Overall mortality was 9.5%, 5.75% being PE-related. Main risk factors enclosed recent respiratory tract infections (55.3%), immobility (42.25%), recent hospital admissions (33.6%) and cancer (30.3%). In 65.8% of patients, PE was associated with deep vein thrombosis. 16.6% of patients had a shock index ≥1 and 84.75% simplified pulmonary embolism severity index (PESI) score ≥1. A number of 51.5% of patients presented echocardiographic right heart dysfunction, 50.6% and 55.9% of patients presented increased values of troponins and natriuretic peptides, respectively. The following percentage, 6.5%, 71.1% and 22.4%, were defined as high, intermediate and low risk according to the European Society of Cardiology (ESC) criteria, respectively. Antithrombotic treatment was started in Internal Medicine wards in 60.6% of patients. 4.9% of patients were treated with systemic thrombolysis, 15.1% with intravenous unfractionated heparin, whereas low molecular weight heparins and fondaparinux were performed in 39.2% and 39.8% of patients, respectively. Vitamin K antagonists were prescribed in 52.1% of patients at hospital discharge. Fatal and non-fatal major bleedings occurred in 1.7% of patients. TUSCAN-PE study contributes to the knowledge of real life management of acute PE in the Internal Medicine setting.

show abstract

Recent respiratory infection and risk of venous thromboembolism: case-control study through a general practice database

Cited by 101 publications

References 15 publications

Increased risk of venous thromboembolism within the first year after Staphylococcus aureus bacteraemia: a nationwide observational matched cohort study

Increased risk of venous thromboembolism within the first year after Staphylococcus aureus bacteraemia: a nationwide observational matched cohort study

Secondary prevention of systemic arterial and recurrent venous thromboembolic events, through extended time anticoagulation with apixaban, in an elderly patient with multiple comorbidities

Characteristics and clinical management of acute pulmonary embolism in real world: findings from TUSCAN-PE Study

Contact Info

Product

Resources

About