Recent Researches in Triazole Compounds as Medicinal Drugs

Abstract

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in biological system via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in triazole-based derivatives as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired. Noticeably, a large number of triazole compounds as clinical drugs or candidates have been frequently employed for the treatment of various types of diseases, which have shown their large development value and wide potential as medicinal agents. This work systematically reviewed the recent researches and developments of the whole range of triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic, anticonvulsant, antiparasitic, antidiabetic, anti-obesitic, antihistaminic, anti-neuropathic, antihypertensive as well as other biological activities. The perspectives of the foreseeable future in the research and development of triazole-based compounds as medicinal drugs are also presented. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic triazole medicinal drugs.

Regioselective formation of 1,2,4-triazoles by the reaction of amidrazones in the presence of diethyl azodicarboxylate and catalyzed by triethylamine

“…Refluxing equimolar amounts of N 1 -arylamidrazones 1a-f with diethyl azodicarboxylate (2) in dry EtOH, catalyzed by a few drops of triethylamine, led to the formation of 4-aryl-5-methyl-3-phenyl-1,2,4-triazoles 3a-f in 68-75% yields and 4-aryl-3,5-diphenyl-1,2,4-triazoles 4a-f in 13-20% yields, together with traces of diethyl hydrazine-1,2-dicarboxylate (5) (Scheme 1). The products were separated by preparative TLC; compounds 4 tended to co-elute with additional 5, which was removed by recrystallization.…”

“…Therefore, triazoles display widespread biological activities. Hence, many triazole derivatives serve as medicinal drugs [2]. Triazoles also have antifungal activities [3].…”

Design, synthesis and biological evaluation of novel 1,2,3-triazolyl $$\upbeta $$ β -hydroxy alkyl/carbazole hybrid molecules

“…Thus, the incorporation of 1,2,3-triazolyl cores into the scaffolds of bioactive molecules is interesting [16,18].…”

Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides

“…More and more triazole derivatives, with strong pharmacological activity, low toxicity, less adverse effects, fewer multi-drug resistances, high bioavailability, good pharmacokinetics property and drug-targeting, diversity of drug administration, broad spectrum, better curative effect etc., A large number of triazole compounds as clinical drugs or candidates have been frequently employed for the treatment of various types of diseases, Triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic,anticonvulsant, antiparasitic, antidiabetic, anti-obesitic, antihista-minic, anti-neuropathic, antihypertensive as well as other biological activities Wang, 2012 andKhabnadideh et al, 2012). In fact several benzotriazoles have shown potential biological activities such as antimycobacterial (Sanna et al, 2002), antitumor (Handratta et al, 2005) and anti-inflammatory (Dawood et al, 2006) activities.…”