Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi

Jia, Buyun; Li, Shanshan; Hu, Xuerui; Zhu, Guangyu; Chen, Weidong

doi:10.1208/s12249-015-0339-4

Cited by 25 publications

(22 citation statements)

References 104 publications

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“…Xanthones and flavones frequently found in nature [8][9][10][11][12][13] correspond to "privileged structures," showing a wide variety of biological activities [9,11,[14][15][16]. Among these activities, the effect on molecular targets of AD have been widely studied and explored [6,[17][18][19][20][21][22].…”

Section: Journal Of Chemistrymentioning

confidence: 99%

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Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

Cruz

Puthongking

Cravo

et al. 2017

Journal of Chemistry

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Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that is associated with the elderly. The current therapy that is used to treat AD is based mainly on the administration of acetylcholinesterase (AChE) inhibitors. Due to their low efficacy there is a considerable need for other therapeutic strategies. Considering that the malfunctions of different, but interconnected, biochemical complex pathways play an important role in the pathogenesis of this disease, a promising therapy may consist in administration of drugs that act on more than a target on biochemical scenery of AD. In this work, the synthesis and evaluation of xanthone and flavone derivatives as antioxidants with AChE inhibitory activity were accomplished. Among the obtained compounds, Mannich bases3and14showed capacity to inhibit AChE and antioxidant property, exerting dual activity. Moreover, for the most promising AChE inhibitors, docking studies on the target have been performed aiming to predict the binding mechanism. The results presented here may help to identify new xanthone and flavone derivatives as dual anti-Alzheimer agents with AChE inhibitory and antioxidant activities.

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Section: Journal Of Chemistrymentioning

confidence: 99%

“…Hydroxy-1-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-methoxy-9H-xanthen-9-one(12). Pale yellow solid (yield: 39%).…”

mentioning

confidence: 99%

Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

Cruz

Puthongking

Cravo

et al. 2017

Journal of Chemistry

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“…Anti-HIV-1 activity of gambogic acid ( 28 ) and morellic acid ( 31 ), by inhibiting the HIV-1 reverse transcriptase enzyme [62] and the antiatherosclerosis activity of gambogic acid ( 28 ) via inhibition of vascular smooth muscle cell proliferation were also significant [75]. The isolation and biological activity evaluation of these compounds have been extensively reviewed by several groups [76,77,78,79,80].…”

Section: Natural Carboxyxanthone Derivativesmentioning

confidence: 99%

Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives

et al. 2019

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Xanthones represent a structurally diverse group of compounds with a broad range of biological and pharmacological activities, depending on the nature and position of various substituents in the dibenzo-γ-pyrone scaffold. Among the large number of natural and synthetic xanthone derivatives, carboxyxanthones are very interesting bioactive compounds as well as important chemical substrates for molecular modifications to obtain new derivatives. A remarkable example is 5,6-dimethylxanthone-4-acetic acid (DMXAA), a simple carboxyxanthone derivative, originally developed as an anti-tumor agent and the first of its class to enter phase III clinical trials. From DMXAA new bioactive analogues and derivatives were also described. In this review, a literature survey covering the report on carboxyxanthone derivatives is presented, emphasizing their biological activities as well as their application as suitable building blocks to obtain new bioactive derivatives. The data assembled in this review intends to highlight the therapeutic potential of carboxyxanthone derivatives and guide the design for new bioactive xanthone derivatives.

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“…Numerous reviews by several research teams have focused on xanthone compounds, a small subset of which are caged xanthones [48][49][50][51][52][53][54][55][56]. In addition, the therapeutic potential of gambogic acid has recently been highlighted in several elegant reviews [57][58][59][60] and a book section [61]. Herein, this review does not attempt to overlap with those excellent published works but instead focuses on the structural diversity and biological investigation of newly isolated caged xanthone compounds from the years 2008 to 2021.…”

Section: Introductionmentioning

confidence: 99%

Structural diversity and biological activities of caged Garcinia xanthones: recent updates

Phang

Zheng

2022

Acta Materia Medica

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Caged xanthones are a class of natural compounds with approximately 200 members that are commonly isolated from the Garcinia genus in the Clusiaceae (formerly Guttiferae) family. They are often characterized by a notable 4-oxa-tricyclo[4.3.1.03,7]dec-2-one (caged) architecture with a common xanthone backbone. Because most caged xanthones have potent anticancer properties, they have become a target of interest in natural product chemistry. The unique chemical architectures and increasingly identified biological importance of these compounds have stimulated many studies and intense interest in their isolation, biological evaluation and mechanistic studies. This review summarizes recent progress and development in the chemistry and biological activity of caged Garcinia xanthones and of several compounds of non-Garcinia origin, from the years 2008 to 2021, providing an in-depth discussion of their structural diversity and medicinal potential. A preliminary discussion on structure-activity relationships is also provided.

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Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi

Cited by 25 publications

References 104 publications

Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives

Structural diversity and biological activities of caged Garcinia xanthones: recent updates

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