Recent Research and Patents on Controlling Corrosion of Bioresorbable Mg Alloy Implants: Towards Next Generation Biomaterials

Heimann, Robert B.; Lehmann, Hans D.

doi:10.2174/1874464810666170621082333

Cited by 5 publications

(8 citation statements)

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“…Moreover, the results have evidenced that the inhibitory effect is dependent on the incubation time and also on the sample concentration in the case of 10MgHAp suspensions. According to [74,75], corrosion products released by modern biocompatible magnesium alloys do not significantly affect human metabolic pathways. Moreover, recent studies [76,77] have shown that implantation of a magnesium device causes minimal changes in blood composition without causing damage to the excretory organs, such as the liver or kidneys.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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Obtaining nanoscale materials has allowed for the miniaturization of components, which has led to the possibility of achieving more efficient devices with faster functions and much lower costs. While hydroxyapatite [HAp, Ca10(PO4)6(OH)2] is considered the most widely used material for medical applications in orthopedics, dentistry, and general surgery, the magnesium (Mg) is viewed as a promising biodegradable and biocompatible implant material. Furthermore, Mg is regarded as a strong candidate for developing medical implants due to its biocompatibility and antimicrobial properties against gram-positive and gram-negative bacteria. For this study, magnesium-doped hydroxyapatite (Ca10−xMgx (PO4)6 (OH)2, xMg = 0.1), 10MgHAp, suspensions were successfully obtained by an adapted and simple chemical co-precipitation method. The information regarding the stability of the nanosized 10MgHAp particles suspension obtained by ζ-potential analysis were confirmed for the first time by a non-destructive ultrasound-based technique. Structural and morphological studies of synthesized 10MgHAp were conducted by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy in attenuated total reflectance (ATR) mode and scanning electron microscopy (SEM). The XRD analysis of the 10MgHAp samples confirmed that a single crystalline phase associated to HAp with an average grain size about 93.3 nm was obtained. The FTIR-ATR spectra revealed that the 10MgHAp sample presented broader IR bands with less visible peaks when compared to a well-crystallized pure HAp. The SEM results evidenced uniform MgHAp nanoparticles with spherical shape. The antimicrobial activity of the 10MgHAp suspension against gram-positive strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212), gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), as well as a fungal strain (Candida albicans ATCC 90029) were evaluated.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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“…Whereas corrosion protection of Mg alloys is predominantly based on conversion coatings consisting of MgO, Mg(OH) 2 or MgF 2 , hydroxylapatite coatings deposited by biomimetic or other low temperature deposition techniques have been shown to reduce substantially the corrosion rate of magnesium [15].…”

Section: Corrosion Protectionmentioning

confidence: 99%

“…aluminum and vanadium ions released from the implant and their interference with normal biochemical functions of the human body are an important intervention to consider and require more study [60]. Consequently, today, developments are on the way to replace Ti6Al4V by low modulus (E < 50 GPa) β-type Zr-containing alloys such as Ti13Nb13Zr free of potentially deleterious Al and V. Whereas corrosion protection of Mg alloys is predominantly based on conversion coatings consisting of MgO, Mg(OH)2 or MgF2, hydroxylapatite coatings deposited by biomimetic or other low temperature deposition techniques have been shown to reduce substantially the corrosion rate of magnesium [15].…”

Section: Corrosion Protectionmentioning

confidence: 99%

“…First among those is the need to improve the corrosion resistance of Mg base alloys by detecting novel biocompatible alloying elements as well as to discover appropriate biocompatible surface treatments that will guarantee long-term in vivo stability of the implant. Such surface treatments will include deposition of bioceramic coatings such as hydroxylapatite [15] and calcium silicates [16] as well as organosilanes [17] and polymeric hydrogels [18].…”

Section: Introductionmentioning

confidence: 99%

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Osseoconductive and Corrosion-Inhibiting Plasma-Sprayed Calcium Phosphate Coatings for Metallic Medical Implants

Heimann

2017

Metals

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During the last several decades, research into bioceramic coatings for medical implants has emerged as a hot topic among materials scientists and clinical practitioners alike. In particular, today, calcium phosphate-based bioceramic materials are ubiquitously used in clinical applications to coat the stems of metallic endoprosthetic hips as well as the surfaces of dental root implants. Such implants frequently consist of titanium alloys, CoCrMo alloy, or austenitic surgical stainless steels, and aim at replacing lost body parts or restoring functions to diseased or damaged tissues of the human body. In addition, besides such inherently corrosion-resistant metals, increasingly, biodegradable metals such as magnesium alloys are being researched for osseosynthetic devices and coronary stents both of which are intended to remain in the human body for only a short time. Biocompatible coatings provide not only vital biological functions by supporting osseoconductivity but may serve also to protect the metallic parts of implants from corrosion in the aggressive metabolic environment. Moreover, the essential properties of hydroxylapatite-based bioceramic coatings including their in vitro alteration in contact with simulated body fluids will be addressed in this current review paper. In addition, a paradigmatic shift is suggested towards the development of transition metal-substituted calcium hexa-orthophosphates with the NaSiCON (Na superionic conductor) structure to be used for implant coatings with superior degradation resistance in the corrosive body environment and with pronounced ionic conductivity that might be utilized in novel devices for electrical bone growth stimulation.

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“…Moreover, some important works can also be found regarding the study of PEO coatings on biodegradable and biocompatible magnesium. In particular, fluoride-containing coatings have been proved to increase the bioactivity of the sample and to delay the degradation for enough time to permit the bone repair [ 26 , 27 , 28 , 29 , 30 ]. The use of fluoride compounds is, however, not recommended due to environmental problems [ 31 ] and, indeed, only few works reported the formation in one step of hydroxyapatite-containing PEO coatings [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Microstructural and Corrosion Properties of Hydroxyapatite Containing PEO Coating Produced on AZ31 Mg Alloy

et al. 2021

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In this work, the composition of an electrolyte was selected and optimized to induce the formation of hydroxyapatite during Plasma electrolytic oxidation (PEO) treatment on an AZ31 alloy for application in bioabsorbable implants. In detail, the PEO process, called PEO-BIO (Plasma Electrolytic Oxidation-Biocompatible), was performed using a silicate-phosphate-based electrolyte with the addition of calcium oxide in direct-current mode using high current densities and short treatment times. For comparison, a known PEO process for producing anticorrosive coatings, called standard, was applied on the same alloy. The coatings were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and XPS analyses. The corrosion performance was evaluated in simulated body fluid (SBF) at 37 °C. The coating produced on the PEO-BIO sample was porous and thicker than the standard PEO one, with zones enriched in Ca and P. The XRD analysis showed the formation of hydroxyapatite and calcium oxides in addition to magnesium-silicon oxide and magnesium oxide in the PEO-BIO sample. The corrosion resistance of PEO-BIO sample was comparable with that of a traditional PEO treated sample, and higher than that of the untreated alloy.

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Recent Research and Patents on Controlling Corrosion of Bioresorbable Mg Alloy Implants: Towards Next Generation Biomaterials

Cited by 5 publications

References 0 publications

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Osseoconductive and Corrosion-Inhibiting Plasma-Sprayed Calcium Phosphate Coatings for Metallic Medical Implants

Microstructural and Corrosion Properties of Hydroxyapatite Containing PEO Coating Produced on AZ31 Mg Alloy

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