Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

Qi, Feng; Wu, Jie; Li, Hao; Ma, Guanghui

doi:10.1007/s11705-018-1729-4

Cited by 112 publications

(96 citation statements)

References 80 publications

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“…Because it is biocompatible and biodegradable, it has become a material of choice in biomedical applications [14][15][16]. This also includes the use of PLA for long-term controlled release of active ingredients [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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A controlled release system of Plai (Zingiber cassumunar Roxb.) oil based on electrospun poly(lactic) acid (PLA) nanofiber mat was successfully developed. The physicochemical properties of the nanofibers loaded with select amounts of oil (15%, 20%, and 30% wt) were characterized using various techniques, including a morphological study using scanning electron microscopy (SEM), structural determination using Fourier transform infrared spectrometry (FTIR) and x-ray diffraction (XRD), as well as thermal properties study using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The loading content and the entrapment efficiency of Plai oil within the fiber mats were evaluated and were found to be remarkably high, ensuring that PLA was an appropriate material for Plai oil loading. The ability of the nanofiber mats to release (E)-1-(3,4dimethoxyphenyl) butadiene (DMPBD) was also examined and the fiber mats showed controlled release characteristics. As the nanofiber mats have particularly high specific surface area with fully accessible and interconnected pore structures, a liquid medium with active ingredients will not be trapped in blind pores but can be fully released out of the fiber matrix. Furthermore, in vitro skin permeation of the active compound as well as a skin irritation were assessed using reconstructed human epidermis (EpiSkin TM ). It was found that DMPBD could efficiently penetrate through the skin model. Moreover, the nanofiber mats containing Plai oil also showed no skin irritation, indicating them as promising prototypes for medical applications.

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Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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“…Today, research on PLA/PLGA microparticulate systems is experiencing a sort of revival. With many approved products on the market, injectable PLA/PLGA microparticles are considered a consistent drug delivery system (Qi et al 2018), and hold particular promise for the delivery of therapeutic peptides, a field of discovery in continuous growth (Lau and Dunn 2018). In addition, with the expiration of the first patents, pharmaceutical companies have been interested in the development of generic PLA/PLGA-based products, a difficult process that will require additional academic, industrial and regulatory research.…”

Section: Prologuementioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Blasi

2019

J. Pharm. Investig.

156

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Background Poly(glycolic acid), poly(lactic acid) and poly(lactic-co-glycolic acid) were approved by the United States Food and Drug Administration (FDA) in the 1970s as materials for the manufacturing of bioresorbable surgical sutures, but soon became the reference materials for the preparation of sustained release formulations, especially injectable microparticles. Since the 1986 approval of Decapeptyl ® SR, the first product based on PLGA microspheres, more than 15 such products have been approved for clinical use. Area covered This article highlights the key steps that brought to the development of injectable poly(lactic acid)/poly(lacticco-glycolic acid) microparticles for the sustained release of active pharmaceutical ingredients. After a brief history of some pioneering works that opened the field of controlled drug delivery, the key steps that led to the development of these polymers and the approval of the first microparticle-based medicinal products are reviewed. Finally, the general characteristics of these polymers are described and the classical preparation method is explained. Expert opinion Poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles are among the most successful drug delivery systems. The recent approval of new medicinal products based on PLGA microspheres is the proof that pharmaceutical companies have continued to exploit this drug delivery technology. The possible development of generics and the continuous discovery of therapeutic peptides will hopefully further the success of microsphere technology.

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“…To date, there are about 20 PLA/PLGA based products approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) mainly aimed to be administered by intramuscular or subcutaneous injection (Table 1) (Silverman et al 2002;Wang et al 2016;Tice 2017;Qi et al 2018;CenterWatch 2019. Other products are to be inserted in the periodontal cavity (e.g., Arestin ® ) or by intra-articular injection (i.e., Zilretta ® ).…”

Section: Pla and Plga Microparticles In The Pharmaceutical Marketmentioning

confidence: 99%

“…With the same scale-up purpose, Orbis Biosciences, Inc. (Orbis Biosciences 2019), founded by Berkland and Fishback, has developed an inkjet device able to produce kg/h and even kg/min particles with dimensions comprised in the range 10 μm to 1 mm. The other important advantages of this technique are the absence of material wastage, reduction of manufacturing cost and process steps (Lee et al 2012;Qi et al 2018). A variant of the process previously described has been reported by Lee et al Droplets were produced using a continuous mode piezoelectric device and particles were recovered after 2 h drying of the ink that was printed on a glass slide.…”

Section: Inkjet Technologymentioning

confidence: 99%

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Schoubben

Ricci

Giovagnoli

2019

J. Pharm. Investig.

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Background Polylactides (PLA) and poly lactide-co-glycolides (PLGA) undoubtedly are among the major drivers in the pharmaceutical market. Their relevance in pharmaceutics and biomedicine is well established in light of their sustainability, safety, tunable biodegradability, and versatility. However, polymer degradability and plasticity can somehow restrain industrial developability of PLA and PLGA formulations, especially in the form of microparticles (MP). Area covered This review wants to deal with the known manufacturing issues of PLA/PLGA MP, debating the potential contribution of modern and cutting-edge manufacturing technologies to the solution of unmet production needs. Technological and regulatory aspects will be considered outlining the potential role of advanced manufacturing techniques in the advancement of PLA/PLGA MP production processes. Expert opinion The multifaceted complexity of PLA/PLGA MP manufacturing processes demands adequate standardization and updated guidelines covering the so far unmet industrialization requirements. Novel and evolving manufacturing technologies will surely support the future development of bench-to-production plant transfer for such products. Careful evaluation of production costs is demanded in order to ensure process sustainability and patient's outreach.

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Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

Cited by 112 publications

References 80 publications

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

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