Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials

Abstract

Taken together, these studies fundamentally deepen our understanding of AD progression and its underlying genetic basis, which in turn informs and improves clinical trial design.

The Mild Cognitive Impairment (MCI) in Searching for its Clinical Identity, Comment of the NEDICES Cohort Data

“…The database of this project is open to investigators and more than 1,800 recognized investigators had applied to use its databases. ADNI has generated hundreds of scientific papers [12][13][14]. I would like to underline some findings.…”

“…The study begins in 2005 with the enrollment of 800 participants from 56 clinical sites of the United States and Canada. The ADNI project had successive participant inclusions (2009,2011), and it will be finished in 2021 [12][13][14]. Other ADNI studies from Europe, Australia and Japan had shared the ADNI primitive aims and methods [12].…”

“…I would like to underline some findings. 1) Subjective memory loss (SML) does not have a clear risk of dementia in the short-term (3-5 years); the NEDICES cohort determines similar findings [14,15]. In the long run of two decades, possibly, SML had a minimal dementia risk [16].…”

“…In the long run of two decades, possibly, SML had a minimal dementia risk [16]. Cognitive normal subjects (some of them have clear biological risks of preclinical AD) and MCI are biologically heterogeneous [14]. One ADNI work divides the MCI into four groups of subjects: one, clinically stable and without AD physiopathology…”

Transient Ischemic Attack and Minor Stroke

“…7 Similarly, changes in hippocampal mean diffusivity and hippocampal connectivity predict cognitive state at 6 and 12 months after a mild stroke. 8 Structural and functional changes, including these subtle changes to hippocampal shape and texture, atrophy in areas outside of hippocampus, and disruption to functional networks are also seen in the course of Alzheimer disease, 9 suggesting that TIA or minor stroke possibly induce a long-term neurodegenerative process.…”