Recent Progresses in Electrochemical DNA Biosensors for SARS-CoV-2 Detection

Abstract

Coronavirus disease 19 (COVID-19) is still a major public health concern in many nations today. COVID-19 transmission is now controlled mostly through early discovery, isolation, and therapy. Because of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the contributing factor to COVID-19, establishing timely, sensitive, accurate, simple, and budget detection technologies for the SARS-CoV-2 is urgent for epidemic prevention. Recently, several electrochemical DNA biosensors have been developed for the rapid monitoring and detection of SARS-CoV-2. This mini-review examines the latest improvements in the detection of SARS-COV-2 utilizing electrochemical DNA biosensors. Meanwhile, this mini-review summarizes the problems faced by the existing assays and puts an outlook on future trends in the development of new assays for SARS-CoV-2, to provide researchers with a borrowing role in the generation of different assays.

Detection of abemaciclib, an anti-breast cancer agent, using a new electrochemical DNA biosensor

“…The sensor functionalization can be prospective method to monitor the conventional drug dosage (Bayraktepe, 2020;Fathi et al, 2020;Foroughi et al, 2021a;Foroughi et al, 2015;Li et al, 2022;Maaref et al, 2018;Moarefdoust et al, 2021). Nanomaterials have shown specific physical and chemical characteristics in a variety of fields (Akca et al, 2021;Farvardin et al, 2020;Foroughi and Jahani, 2022;Foroughi and Ranjbar, 2017;Mei et al, 2022;Salajegheh et al, 2019;Zhou et al, 2022).…”

An overview of electrochemical biosensors used for COVID-19 detection

“…47 Biosensors aimed at detecting the nucleic acid of the virus allow for direct analysis of the viral genetic material present in the sample, and are also known as DNA biosensors or genosensors. 25,53,63 The article by Wu et al 65 . describes the development of an electrochemical biosensor for the rapid, highly sensitive, and specic detection of the SARS-CoV-2 Delta variant without the need for any nucleic acid amplication assays.…”

“…Additionally, these biosensors are highly efficient and cost-effective, making them an attractive option for SARS-CoV-2 detection. 25,62,63 For instance, in the work conducted by Zukauskas et al (2023) 64 the biosensor was developed using a gold disk electrode modied with a self-assembled monolayer of mercaptoacetic acid (MAA) and 6-mercapto-1-hexanol (6-MCOH). The biosensor was tested for the determination of antibodies against the SARS-CoV-2 spike protein in human serum samples, with detection carried out using three electrochemical methods: cyclic voltammetry, differential pulse voltammetry, and potentiostatic pulsed amperometry.…”

“…Additionally, these biosensors are highly efficient and cost-effective, making them an attractive option for SARS-CoV-2 detection. 25,62,63…”

Metal-organic frameworks/metal nanoparticles as smart nanosensing interfaces for electrochemical sensors applications: a mini-review

“…Finally, their concentration signals are converted into recognizable electrical signals, such as current, voltage and impedance, etc. Due to their simple operation, economy, convenient detection, high sensitivity, and fast response, electrochemical biosensors have been widely used in biomedicine, food engineering, environmental monitoring, and other fields ( Chen et al, 2018 ; Huang et al, 2020 ; Lin et al, 2021a ; Lin et al, 2021b ; Mei et al, 2022a ; Mei et al, 2022b ; Huang et al, 2022 ). It is well known that the sensor interface materials of electrochemical sensors play an important role in the efficient and sensitive detection of different target molecules.…”