Recent progress on synthetic and protein-based genetically encoded sensors for fluorimetric Cu(<scp>i</scp>) recognition: binding and reaction-based approaches

Kumar, Sushil; Goswami, Tapas; Kaushal, Jolly; Kumar, Pankaj; Kumar, Pramod

doi:10.1039/d1sd00065a

Cited by 3 publications

(1 citation statement)

References 128 publications

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“…As a part of our ongoing research in the design and development of new optical probes, [58][59][60][61][62][63][64][65] herein we present an easily synthesizable indole-based chromofluorogenic Schiff base probe (InNS; Figure 1(a)) for recognition of trivalent Al 3 + , Ga 3 + , In 3 + and Fe 3 + ions over other mono-and bivalent cationic species. In this probe, the indole moiety acted as a fluorophore while a combination of both hard (imine-N) and soft (À SÀ ) donor sites served as the metal ion recognition unit.…”

Section: Introductionmentioning

confidence: 99%

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions

Heena,

Yadav,

Saini

et al. 2024

ChemPlusChem

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An easily synthesizable indole‐derived chromofluorogenic probe InNS has been demonstrated for recognition of trivalent metal ions (i.e., Al3+, Ga3+, In3+ and Fe3+). Both UV‐Vis and emission spectral studies have been employed to assess the cation sensing ability of InNS in semi‐aqueous medium. This probe exhibited a chromogenic response for these metal ions which was accompanied with the appearance of a new absorption near 376 nm. An obvious color change from pale yellow to dark yellow could also be noticed upon addition of the aforementioned metal ions to the probe’s solution. Distinctively from the UV‐Vis analysis, the fluorescence behavior of InNS was completely different; it displayed a ‘turn‐on’ fluorescence response for only Al3+ among all the studied cations. The detection limit and association constant (Ka) for Al3+ were determined to be 12.5 nM and 6.85 x 106 M‐1, respectively. A potential 1:1 binding mode of Al3+‐InNS has been established based on Job’s plot, 1H NMR and DFT analyses. The reversibility experiment was conducted using strongly chelating EDTA ion, and a corresponding logic gate has been devised. In terms of practical applications, the InNS has been utilized to detect Al3+ in human breast carcinoma (MCF‐7) cell lines displaying promising ‘turn‐on’ bioimaging experiments.

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Section: Introductionmentioning

confidence: 99%

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions

Heena,

Yadav,

Saini

et al. 2024

ChemPlusChem

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Genetically encoded fluorescent sensors for metals in biology

Torres‐Ocampo

Palmer

2023

Current Opinion in Chemical Biology

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Recent trends in fluorescent-based copper (II) chemosensors and their biomaterial applications

Rajasekar

Agash

Narendran

et al. 2023

Inorganic Chemistry Communications

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Recent progress on synthetic and protein-based genetically encoded sensors for fluorimetric Cu(i) recognition: binding and reaction-based approaches

Abstract: Due to an extensive range of biological significance and applications, the development of different fluorescent probes for Cu ions has been an active area of research over the past 10...

Cited by 3 publications

References 128 publications

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions

Genetically encoded fluorescent sensors for metals in biology

Recent trends in fluorescent-based copper (II) chemosensors and their biomaterial applications

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Recent progress on synthetic and protein-based genetically encoded sensors for fluorimetric Cu(i) recognition: binding and reaction-based approaches

Abstract: Due to an extensive range of biological significance and applications, the development of different fluorescent probes for Cu ions has been an active area of research over the past 10...

Cited by 3 publications

References 128 publications

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al3+, Ga3+, In3+ and Fe3+ Ions

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al3+, Ga3+, In3+ and Fe3+ Ions

Genetically encoded fluorescent sensors for metals in biology

Recent trends in fluorescent-based copper (II) chemosensors and their biomaterial applications

Contact Info

Product

Resources

About

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions

An Indole‐based Chromofluorogenic Probe for Detection of Trivalent Al³⁺, Ga³⁺, In³⁺ and Fe³⁺ Ions