Recent progress on phytochemistry and pharmacological activities of Grewia asiatica L. (Tiliaceae) and traditional uses

Swain, Surendra; Bej, Shuvasree; Mandhata, Chinmayee Priyadarsani; Bishoyi, Ajit Kumar; Sahoo, Chita Ranjan; Padhy, Rabindra N.

doi:10.1016/j.sajb.2023.02.016

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…Quinic acid, considered another important ingredient, exhibits a concentration approximately 1.5 times greater in the aqueous extract compared to the methanol extract. Furthermore, research has indicated that quinic acid and its derivatives possess notable properties such as anti‐cancer, antioxidant, antihistaminic, and antibacterial effects [24] . Furthermore, it is noteworthy that this particular compound ranks third among the cyanidin‐3‐ O ‐glycoside anthocyanosides found in methanol extract.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, research has indicated that quinic acid and its derivatives possess notable properties such as anti-cancer, antioxidant, antihistaminic, and antibacterial effects. [24] Furthermore, it is noteworthy that this particular [21] (1-35th sorted by numbers; quinic acid, fumaric acid, gallic acid, pyrogallol, keracyanin chloride, cyanidin-3-O-glycoside, chlorogenic acid, catechin, peonidin-3-O-glycoside, 4-hydroxybenzoic acid, epicatechin, epigallocatechin gallate, caffeic acid, vanillic acid, syringic acid, vitexin, naringin, ellagic acid, hesperidin, p-coumaric acid, sinapic acid, taxifolin, ferulic acid, rosmarinic acid, vanillin, myricetin, resveratrol, luteolin, quercetin, apigenin, naringenin, isorhamnetin, chrysin, galangin, curcumin). This substance exhibits antioxidant, anti-inflammatory, anticancer and immunomodulatory properties and has been shown to have positive effects upon gastrointestinal and liver health.…”

Section: Lc-ms/ms Analysismentioning

confidence: 99%

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Phenolic Compounds of Phlomis tuberosa by LC–MS/MS‐Determination of Antioxidant Activity, Molecular Docking, and Enzyme Inhibition Profiles

Guven,

Erturk,

Koca

et al. 2023

ChemistrySelect

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Phlomis species have traditionally been employed for the treatment of a number of ailments such as influenza, the common cold, asthma, bronchitis, coughs, hemorrhoids, ulcers, and gastrointestinal disorders. The goal of this study is to compare the anti‐diabetic, anti‐glaucoma, and anti‐Alzheimer's properties and antioxidant activities of methanol (MEPT) and aqueous (WEPT) extracts from the aerial part of P. tuberosa L. Tandem mass spectrometry and liquid chromatography (LC–MS/MS) were used to investigate the compounds of MEPT and WEPT. The inhibitory effects of MEPT and WEPT on the enzymes acetylcholinesterase (AChE), carbonic anhydrase II (CA II) and α‐glycosidase were investigated and molecular docking studies demonstrated binding interactions between the major compounds chlorogenic acid, cyanidin‐3‐O‐glycoside, quinic acid, rosmarinic acid with AChE, CA II and α‐glycosidase enzymes. In addition to that, the total content of phenols and flavonoids was analyzed. Furthermore, the antioxidant activity was evaluated by DPPH, ABTS, DMPD, ferrous ions (Fe2+) chelating, FRAP, CUPRAC, and ferric ions (Fe3+) reducing methods. This study is the first of its kind to show that MEPT and WEPT possess inhibitory effects on AChE, CA II and α‐glycosidase, as well as displaying antioxidant properties.

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Section: Resultsmentioning

confidence: 99%

Section: Lc-ms/ms Analysismentioning

confidence: 99%

Phenolic Compounds of Phlomis tuberosa by LC–MS/MS‐Determination of Antioxidant Activity, Molecular Docking, and Enzyme Inhibition Profiles

Guven,

Erturk,

Koca

et al. 2023

ChemistrySelect

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“…There have been no studies regarding gold nanoparticle synthesized from this locally occurring phalsa. It is used for instant cooling the body in summer, maintaining electrolyte balance and soothing joint aches, and effectively managing seasonal and chronic conditions (Swain et al 2023). It has a high level of vitamin C, minerals, proteins, phenolics, avonoids, tannins and anthocyanins.…”

Section: Introductionmentioning

confidence: 99%

Grewia asiatica leaves extract assisted green synthesis of gold nanoparticles and study of their antibacterial, antioxidant and photocatalytic potential

Maryam,

Akhter,

Qamar

et al. 2024

Preprint

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The environmental issues generated by industrial advancement and human activities are serious and must not be overlooked. Bio-nanotechnology has emerged as a solution for producing biosynthetic nanomaterials to address environmental issues. The current work describes for the first time an economical and environmentally benign method of producing gold nanoparticles utilizing Grewia asiatica (GAAuNPs). The optimal AuNPs were produced using a gold ion concentration of 1 mM and a metal-to-extract ratio of 1:1. The resulting nanoparticles were analyzed and characterized using X-ray crystallography, FTIR, SEM, EDX, and UV visible spectroscopy. The catalytic methylene blue (MB) dye degradation properties, antibacterial and biofilm inhibition abilities, and antioxidant properties of the synthesized particles were investigated. The Au NPs demonstrated efficient catalytic degradation against MB and completely degraded it in 8 minutes. The NPs also exhibited potent biofilm inhibition against E. coli and S. aureus that was close to the standard and was more antioxidant than the standard. The findings highlight G. asiatica as a suitable, inexpensive biosource for biofabricating GAAuNPs with extensive multifunctional uses. To conclude, GAAuNPs' ability to degrade organic pollutants and eradicate pathogens provides a cost-effective and environmentally benign remedy to tackle contemporary pollutants.

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“…Phytochemicals, with their diverse bioactive compounds, offer a rich repository for the identification of novel anticancer molecules with minimal side effects compared to conventional chemotherapy agents. The integration of bioinformatics tools further enhances this process by enabling the rapid and precise analysis of vast biochemical datasets, facilitating the identification of potential lead compounds ( Sharma et al, 2022 ; Swain et al, 2023 ). These computational methods allow for the prediction of compound–target interactions, bioactivity, and the pharmacokinetic properties of phytochemicals, streamlining the drug development process.…”

Section: Introductionmentioning

confidence: 99%

From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches

Alblihy

2024

Front. Pharmacol.

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Ovarian cancer, often labeled a “silent killer,” remains one of the most compelling and challenging areas of cancer research. In 2019 alone, a staggering 222,240 new cases of ovarian cancer were reported, with nearly 14,170 lives tragically lost to this relentless disease. The absence of effective diagnostic methods, increased resistance to chemotherapy, and the heterogeneous nature of ovarian cancer collectively contribute to the unfavorable prognosis observed in the majority of cases. Thus, there is a pressing need to explore therapeutic interventions that offer superior efficacy and safety, thereby enhancing the survival prospects for ovarian cancer patients. Recognizing this potential, our research synergizes bioinformatics with a network pharmacology approach to investigate the underlying molecular interactions of Saudi Arabian flora (Onopordum heteracanthum, Acacia ehrenbergiana, Osteospermum vaillantii, Cyperus rotundus, Carissa carandas, Carissa spinarum, and Camellia sinensis) in ovarian cancer treatment. At first, phytoconstituents of indigenous flora and their associated gene targets, particularly those pertinent to ovarian cancer, were obtained from open-access databases. Later, the shared targets of plants and diseases were compared to identify common targets. A protein–protein interaction (PPI) network of predicted targets was then constructed for the identification of key genes having the highest degree of connectivity among networks. Following that, a compound–target protein–pathway network was constructed, which uncovered that, namely, hispidulin, stigmasterol, ascorbic acid, octopamine, cyperene, kaempferol, pungenin, citric acid, d-tartaric acid, beta-sitosterol, (−)-epicatechin gallate, and (+)-catechin demonstrably influence cell proliferation and growth by impacting the AKT1 and VEGFA proteins. Molecular docking, complemented by a 20-ns molecular dynamic (MD) simulation, was used, and the binding affinity of the compound was further validated. Molecular docking, complemented by a 20-ns MD simulation, confirmed the binding affinity of these compounds. Specifically, for AKT1, ascorbic acid showed a docking score of −11.1227 kcal/mol, interacting with residues Ser A:240, Leu A:239, Arg A:243, Arg C:2, and Glu A:341. For VEGFA, hispidulin exhibited a docking score of −17.3714 kcal/mol, interacting with Asn A:158, Val A:190, Gln B:160, Ser A:179, and Ser B:176. To sum up, both a theoretical and empirical framework were established by this study, directing more comprehensive research and laying out a roadmap for the potential utilization of active compounds in the formulation of anti-cancer treatments.

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Recent progress on phytochemistry and pharmacological activities of Grewia asiatica L. (Tiliaceae) and traditional uses

Cited by 8 publications

References 34 publications

Phenolic Compounds of Phlomis tuberosa by LC–MS/MS‐Determination of Antioxidant Activity, Molecular Docking, and Enzyme Inhibition Profiles

Phenolic Compounds of Phlomis tuberosa by LC–MS/MS‐Determination of Antioxidant Activity, Molecular Docking, and Enzyme Inhibition Profiles

Grewia asiatica leaves extract assisted green synthesis of gold nanoparticles and study of their antibacterial, antioxidant and photocatalytic potential

From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches

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