Recent progress on motion control of swimming micro/nanorobots

Yu, Shimin; Cai, Yang; Wu, Zhiguang; He, Qiang

doi:10.1002/viw.20200113

Cited by 28 publications

(17 citation statements)

References 121 publications

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“…Magnetic fields are arguably the most widely tested actuation methods to drive the motion of swimming microrobots ( Yang and Zhang, 2020 ; Shao et al, 2021 ). However, other approaches such as ultrasound or light have also been explored, along with self-navigating methods based on chemotaxis, phototaxis, magnetotaxis, gravitaxis, and rheotaxis ( Yu et al, 2021 ). Interestingly, swimming microrobots have become an area of intense study for targeted drug delivery to neurons ( Dong et al, 2020 ; Kim et al, 2020 ).…”

Section: Future Horizons: Can Tiny Machines Target Transactivation Re...mentioning

confidence: 99%

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease

Sekar

Tusubira²,

Ross³

2022

Front. Cell. Neurosci.

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Understanding and ameliorating neurodegenerative diseases represents a key challenge for supporting the health span of the aging population. Diverse protein aggregates have been implicated in such neurodegenerative disorders, including amyloid-β, α-synuclein, tau, fused in sarcoma (FUS), and transactivation response element (TAR) DNA-binding protein 43 (TDP-43). Recent years have seen significant growth in our mechanistic knowledge of relationships between these proteins and some of the membrane-less nuclear structures that fulfill key roles in the cell function. These include the nucleolus, nuclear speckles, and paraspeckles. The ability of macromolecular protein:RNA complexes to partition these nuclear condensates through biophysical processes that involve liquid–liquid phase separation (LLPS) has also gained attention recently. The paraspeckle, which is scaffolded by the architectural long-non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) plays central roles in RNA processing and metabolism and has been linked dynamically to TDP-43. In this mini-review, we outline essential early and recent insights in relation to TDP-43 proteinopathies. We then appraise the relationships between TDP-43 and NEAT1 in the context of neuronal paraspeckles and neuronal stress. We highlight key areas for investigation based on recent advances in our understanding of how TDP-43 affects neuronal function, especially in relation to messenger ribosomal nucleic acid (mRNA) splicing. Finally, we offer perspectives that should be considered for translational pipelines in order to improve health outcomes for the management of neurodegenerative diseases.

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Section: Future Horizons: Can Tiny Machines Target Transactivation Re...mentioning

confidence: 99%

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease

Sekar

Tusubira²,

Ross³

2022

Front. Cell. Neurosci.

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“…To understand how an attraction to fuelling components is realized in artificial systems despite them lacking any complex receptors, and to disentangle and model the separate physical contributions, different chemotaxis assays have been created. [116][117][118] The experimental challenges on how to create a controlled and stable gradient in the vicinity of the microswimmers, [119,120] avoiding overlaying flows or capillarity has been solved recently by Xiao et al, by developing a technically refined strategy for gradient generation. Microfluidics combined with a stopped-flow technique was used to perform a chemotaxis assay with artificial Janus microswimmers.…”

Section: Chemotaxismentioning

confidence: 99%

Colloidal Active Matter Mimics the Behavior of Biological Microorganisms—An Overview

Nsamela

Zintzun

Montenegro‐Johnson

et al. 2022

Small

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resources from the environment into building blocks and provides energy, and the capacity to pass on some form of inheritable information to the next generation. [1] The creation of artificial life-able to replicate these behaviors-is extensively studied with droplets, vesicles, [2] and DNA nanotechnology. [3] However, these exciting approaches belong to synthetic biology and are reviewed in detail in other excellent reviews. [4] While bio-inspiration has long been a driver for game-changing developments such as airplanes, submarines, radar, and water-repelling surfaces, on the small scale we see yet relatively few such developments. [5] There are fascinating micro-organisms that have evolved over billions of years, and over the course of this process they managed to adapt in different environments. The integration of living beings into their environment is a dynamic process that requires reaction and adaptation to external conditions and stimuli; it is all the more impressive, therefore, that some bacteria have adapted to water and land, but socalled thermo-and extremophiles have even adapted to survive the harshest conditions. Potential uses for smart small scale devices are plentiful, and range from drug delivery to sensing and environmental remediation, with specific literature available on all of these. [6][7][8] The first step is often assumed to be the ability to sense certain physical or chemical changes in the surroundings, and then evaluate which condition is more favorable and adapt accordingly. Artificial micromotors mimic biological microswimmers (Figure 1) in a fully synthetic way, giving microdevices motility, previously the attribute of living systems. Due to the small scale of these devices, their sensing and signal processing capabilities are very limited; yet still, several resemblances with living microswimmers have been observed and studied, and often impressive similarities or even additional understanding can be found. The goal of this review paper is to summarize recent progress in this area, and to give insight into the physical backgrounds of such biomimetic behaviors. Comparison of Biological and Synthetic Active MatterBiological microorganisms, often referred to as "microbes," are a highly diversified collection of living entities from all three branches of the tree of life: Bacteria and Archaea, which are This article provides a review of the recent development of biomimicking behaviors in active colloids. While the behavior of biological microswimmers is undoubtedly influenced by physics, it is frequently guided and manipulated by active sensing processes. Understanding the respective influences of the surrounding environment can help to engineering the desired response also in artificial swimmers. More often than not, the achievement of biomimicking behavior requires the understanding of both biological and artificial microswimmers swimming mechanisms and the parameters inducing mechanosensory responses. The comparison of both classes of microswimmers provides with analogies in thei...

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“…Combined with the bacterial bio-based micro-nano robot, the gradient of temperature, pH, oxygen and temperature difference can be used to guide this type robots' swimming direction. [34,148] Biological Biological micro-nano robots based on biological materials and bionic micro-nano robots based on biological structures. It has high biocompatibility and biodegradability, and it is difficult to control technology.…”

Section: Chemicalmentioning

confidence: 99%

Recent Advances in Field‐Controlled Micro–Nano Manipulations and Micro–Nano Robots

Chen

Liang

et al. 2021

Advanced Intelligent Systems

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Figure 6. Recent research and applications of acoustic control. A) Acoustic controlled RBC-PL-robot for removal of pathogenic bacteria and toxins.Reproduced with permission. [115] Copyright 2017, ACS. B) Acoustic controlled rotation of microbeads and oocytes. Reproduced with permission. [116] Copyright 2019, AIP. C) Acoustic controlled nanoswimmer for propulsion to maneuver micro-/nanosized objects. Reproduced with permission. [118] Copyright 2019, ACS. D) An untethered ultrasound-controlled actuator for targeted drug delivery. Reproduced with permission. [119] Copyright 2019, Springer Nature. E) Acoustic controlled micro rotor in PDMS channel for microelectromechanical systems. Reproduced with permission. [120]

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Recent progress on motion control of swimming micro/nanorobots

Cited by 28 publications

References 121 publications

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease

Colloidal Active Matter Mimics the Behavior of Biological Microorganisms—An Overview

Recent Advances in Field‐Controlled Micro–Nano Manipulations and Micro–Nano Robots

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