Recent Progress on Copper-Mediated Directing-Group-Assisted C(sp2)–H Activation

Shang, Maoyu; Sun, Shang‐Zheng; Wang, Hongli; Wang, Ming‐Ming; Dai, Hui‐Xiong

doi:10.1055/s-0035-1562795

Cited by 79 publications

(6 citation statements)

References 61 publications

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“…It is worth mentioning that the covered examples were selected based on evidence for reaction mechanisms involving a metal-mediated C-H activation through the formation of cyclometalated species and applications in medicinal chemistry. The field of copper-mediated functionalization of C-H bonds is much broader and has been covered by excellent reviews [333][334][335][336].…”

Section: Copper-catalyzed C-h Activationmentioning

confidence: 99%

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

Carvalho¹,

Miranda²,

Nunes³

et al. 2021

Beilstein J. Org. Chem.

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Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.

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Section: Copper-catalyzed C-h Activationmentioning

confidence: 99%

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

Carvalho¹,

Miranda²,

Nunes³

et al. 2021

Beilstein J. Org. Chem.

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“…They finally obtained oxidation products with 80–86 % yield and 92–99 % ee after 20 min with 5 g scale. In addition to this, another article discussed the porphyrin‐inspired N 4 ligands L1 and iron complex to afford the corresponding epoxides for trisubstituted cyclic enones 3 (Scheme b) . As a result of electronic effects, electron‐withdrawing substituents at the ortho or para positions of the substrates showed a negative effect on the yields.…”

Section: Homogeneous Enantioselective Catalysis In Flowmentioning

confidence: 99%

Recent Advances in Continuous‐Flow Enantioselective Catalysis

Ding

Nie

et al. 2020

Chemistry A European J

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The increased demand for more efficient, safe, and green production in fine chemical and pharmaceutical industry calls for the development of continuous-flowm anufacturing, and for chiral chemicals in particular,e nantioselective catalytic processes. In recenty ears, this emerging direction has received considerable attention and has seen rapid progress. In most cases, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode,s uch as shortened reaction times, lower catalysts loadings, andh igher selectivities in addition to the normalm erits of non-enantioselective flow operations. In this Minireview,t he advancements, key strategies, methods, and technologiesd eveloped the last six years as well as remaining challenges are summarized.[a] T.

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“…However, only simple benzamide scaffolds were used in these couplings. 28 Moreover, to the best of our knowledge, no examples dealing with the directed copper-catalyzed C–H amination of non-aromatic Csp 2 –H bonds exist in the literature.…”

Section: Introductionmentioning

confidence: 99%