Recent progress on Catellani reaction

Palladium/norbornene/copper-catalysed intermolecular thio-esterification from ketones: modular access towards tetrasubstituted vinyl sulfides

“…Two different functional groups can be installed simultaneously at vicinal positions of the aromatics through coupling with an electrophile and a terminating agent by leveraging the unique reactivity of an aryl-norbornyl palladacycle intermediate. 15,16 Compared with the considerable progress achieved in the area of arene functionalization, extension of the Pd/NBE chemistry to partial or nonaromatic substrates, such as alkenes, remains under-developed. 17 The crux for the success of this transformation lies in forming an alkenyl-norbornyl palladacycle over competing migratory insertion of norbornyl–Pd species into alkenyl π-bonds, which would produce undesired cyclopropanes.…”

Direct Synthesis of C4-Acyl Indoles via C–H Acylation

“…Palladium/Norbornene (Pd/NBE) chemistry, as a powerful method to achieve ortho C–H functionalization of halogenated benzene, was first discovered by Catellani . Subsequently, Lautens reported on the palladium and norbornene-catalyzed tandem cyclization reaction, which has been widely applied to the chemical synthesis of natural products and drugs; thus, it is also known as the Catellani–Lautens cyclization strategy .…”