Recent Progress on Bioresorbable Passive Electronic Devices and Systems

Wei, Zhihuan; Xue, Zhongying; Guo, Qinglei

doi:10.3390/mi12060600

Cited by 9 publications

(7 citation statements)

References 103 publications

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“…Several natural polymers, including proteins (silk [108][109][110] and collagen [111][112][113] ) and polysaccharides (chitosan [114] and starch [22,115] ), or synthetic polymers, such as poly(lactic-co-glycolic acid) (PLGA) [22,[116][117][118] , are some examples of commonly used polymers for encapsulation [1,7,70,75,94,95,106] . Such polymers draw attention due to their biocompatible nature, water solubility, tunable dissolution rate, and mechanical properties for their use as transient water barriers [70,75,95,97] .…”

Section: Organic Encapsulationsmentioning

confidence: 99%

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

Park,

Ryu,

Choi

et al. 2024

Soft Sci

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Biodegradable electronics have revolutionized the field of medical devices by offering inherent advantages such as natural disintegration after a useful functional period, thereby eliminating the need for removal surgery. This paradigm shift addresses challenges with long-term implantation, the risks of secondary surgeries, and potential complications, offering a safer and more patient-friendly approach to temporary implantable devices. This review delves into the dissolution kinetics of materials and strategies for lifetime control providing a comprehensive overview of recent advancements in biodegradable electronics. Understanding the kinetics is crucial for meeting the required functional lifetime for implantable medical applications, which varies based on application scope and target diseases. The dissolution kinetics of silicon and biodegradable metals form the core of the discussion, focusing on recent studies aimed at controlling the dissolution rate and enhancing properties. The exploration extends to ideas for accelerating material degradation or initiating on-demand degradation in biodegradable electronics after stable function. Additionally, the compilation of encapsulation layer materials and strategies enhances understanding of how to improve the stable operation time of devices. Emphasis is placed on efforts to adjust the lifetime of biodegradable electronics, particularly in medical applications.

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Section: Organic Encapsulationsmentioning

confidence: 99%

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

Park,

Ryu,

Choi

et al. 2024

Soft Sci

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“…Biodegradable therapeutic devices have gained tremendous momentum in the last decade, thanks to advances in modulation processes and novel processing technologies for flexible, stretchable degradable materials (Long et al, 2018;Cha et al, 2019;La Mattina et al, 2020;Wei et al, 2021). In 2014, Omenetto and colleagues demonstrated a programmable transient thermal therapy system for surgical site disinfection and anti-infection using a silk substrate and encapsulation with magnesium metal as the heating resistor (Figure 7A) (Tao et al, 2014).…”

Section: Biodegradable Therapeutic Electronicsmentioning

confidence: 99%

Biodegradable polymeric materials for flexible and degradable electronics

2022

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Biodegradable electronics have great potential to reduce the environmental footprint of electronic devices and to avoid secondary removal of implantable health monitors and therapeutic electronics. Benefiting from the intensive innovation on biodegradable nanomaterials, current transient electronics can realize full components’ degradability. However, design of materials with tissue-comparable flexibility, desired dielectric properties, suitable biocompatibility and programmable biodegradability will always be a challenge to explore the subtle trade-offs between these parameters. In this review, we firstly discuss the general chemical structure and degradation behavior of polymeric biodegradable materials that have been widely studied for various applications. Then, specific properties of different degradable polymer materials such as biocompatibility, biodegradability, and flexibility were compared and evaluated for real-life applications. Complex biodegradable electronics and related strategies with enhanced functionality aimed for different components including substrates, insulators, conductors and semiconductors in complex biodegradable electronics are further researched and discussed. Finally, typical applications of biodegradable electronics in sensing, therapeutic drug delivery, energy storage and integrated electronic systems are highlighted. This paper critically reviews the significant progress made in the field and highlights the future prospects.

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“…To the best of our knowledge, no demonstration of in vivo operation of bioresorbable chemical or pH sensors has been given to date. [ 2 , 23 ]…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, no demonstration of in vivo operation of bioresorbable chemical or pH sensors has been given to date. [2,23] Among the many analytes of clinical interest, the concentration of H + , that is, the pH value, is of utmost importance for acidbase regulation. [24][25][26] The concentration of H + in blood plasma and various other body fluids is among the most tightly regulated variables in human physiology.…”

Section: Introductionmentioning

confidence: 99%

Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

et al. 2022

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Here, the authors report on the manufacturing and in vivo assessment of a bioresorbable nanostructured pH sensor. The sensor consists of a micrometer‐thick porous silica membrane conformably coated layer‐by‐layer with a nanometer‐thick multilayer stack of two polyelectrolytes labeled with a pH‐insensitive fluorophore. The sensor fluorescence changes linearly with the pH value in the range 4 to 7.5 upon swelling/shrinking of the polymer multilayer and enables performing real‐time measurements of the pH level with high stability, reproducibility, and accuracy, over 100 h of continuous operation. In vivo studies carried out implanting the sensor in the subcutis on the back of mice confirm real‐time monitoring of the local pH level through skin. Full degradation of the pH sensor occurs in one week from implant in the animal model, and its biocompatibility after 2 months is confirmed by histological and fluorescence analyses. The proposed approach can be extended to the detection of other (bio)markers in vivo by engineering the functionality of one (at least) of the polyelectrolytes with suitable receptors, thus paving the way to implantable bioresorbable chemical sensors.

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Recent Progress on Bioresorbable Passive Electronic Devices and Systems

Cited by 9 publications

References 103 publications

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

Biodegradable polymeric materials for flexible and degradable electronics

Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

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