Recent progress of small-molecule-based theranostic agents in Alzheimer's disease

Gao, Furong; Chen, Jiefang; Zhou, Yuancun; Cheng, Letong; Hu, Ming; Wang, Xiaohui

doi:10.1039/d3md00330b

Cited by 3 publications

(1 citation statement)

References 97 publications

(121 reference statements)

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“…[21][22][23][24][25][26] Therefore, developing theranostic fluorescent probes with efficient blood brain barrier permeability, Ab selectivity, accurate quantitative detection, low toxicity, therapeutic efficacy and high affinity towards both soluble and insoluble Ab species would be a promising strategy and valuable approach for both diagnosis and drug development of AD. [27][28][29][30] Previously, we have developed NIR fluorescent probes for both soluble and insoluble Ab species detection and in vivo imaging in AD models. 9,10,31,32 We have also developed a gadolinium(III) complex-cyanine molecular probe for magnetic resonance imaging (MRI) with a promising theranostic capability of diagnosis and therapy for AD.…”

Section: Introductionmentioning

confidence: 99%

Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease

Iyaswamy,

Wang,

Zhang

et al. 2024

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease

Iyaswamy,

Wang,

Zhang

et al. 2024

J. Mater. Chem. B

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ROF‐2 as an Aggregation‐Induced Emission (AIE) Probe for Multi‐Target Amyloid Detection and Screening of Amyloid Inhibitors

Tang,

Zhang,

Zheng

2024

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Misfolding and aggregation of amyloid peptides into β‐structure‐rich fibrils represent pivotal pathological features in various neurodegenerative diseases, including Alzheimer's disease (AD), type II diabetes (T2D), and medullary thyroid carcinoma (MTC). The development of effective amyloid detectors and inhibitors for probing and preventing amyloid aggregation is crucial for diagnosing and treating debilitating diseases, yet it poses significant challenges. Here, an aggregation‐induced emission (AIE) molecule of ROF2 with multifaceted functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays, are reported. As an amyloid probe, ROF2 outperformed ThT, demonstrating its superior sensing capability in monitoring, detecting, and distinguishing amyloid aggregates of different sequences (Amyloid‐β, human islet amyloid polypeptide, or human calcitonin) and sizes (monomers, oligomers, or fibrils). More importantly, the utilization of ROF2 as a screening molecule to identify and repurpose cardiovascular drugs as amyloid inhibitors is introduced. These drugs exhibit potent amyloid inhibition properties, effectively preventing amyloid aggregation and reducing amyloid‐induced cytotoxicity both in cells and nematode. The findings present a novel strategy to discovery AIE‐based amyloid probes and to be used to repurpose amyloid inhibitors, expanding diagnostic and therapeutic options for neurodegenerative diseases while addressing vascular congestion and amyloid aggregation risks.

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Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

Zhou,

Zhu,

Gao

et al. 2024

Dalton Trans.

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Recent progress of small-molecule-based theranostic agents in Alzheimer's disease

Abstract: Alzheimer’s disease (AD) is the most common forms of neurodegenerative dementia. As a multifactorial disease, AD involves several etiopathogenic mechanisms, in which multiple pathological factors are interconnected with each other....

Cited by 3 publications

References 97 publications

Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease

Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease

ROF‐2 as an Aggregation‐Induced Emission (AIE) Probe for Multi‐Target Amyloid Detection and Screening of Amyloid Inhibitors

Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

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