Recent progress of near-infrared fluorescent probes in the determination of reactive oxygen species for disease diagnosis

Lin, Shufang; Ye, Chenqian; Lin, Zengyan; Huang, Luqiang; Li, Daliang

doi:10.1016/j.talanta.2023.125264

Cited by 10 publications

(3 citation statements)

References 79 publications

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“…ROS refer to unstable and reactive forms of oxygen derivatives that are generated as a result of regular metabolic processes [26,27]. ROS generation is a major cellular mechanism underlying the effects of IH.…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

Takeda,

Kimura,

Takasawa

2024

Life

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Intermittent hypoxia (IH) is a central characteristic of sleep apnea syndrome (SAS), and it subjects cells in the body to repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Since SAS is linked to various serious cardiovascular complications, especially hypertension, many studies have been conducted to elucidate the mechanism of hypertension induced by SAS/IH. Hypertension in SAS is associated with numerous cardiovascular disorders. As hypertension is the most common complication of SAS, cell and animal models to study SAS/IH have developed and provided lots of hints for elucidating the molecular mechanisms of hypertension induced by IH. However, the detailed mechanisms are obscure and under investigation. This review outlines the molecular mechanisms of hypertension in IH, which include the regulation systems of reactive oxygen species (ROS) that activate the renin–angiotensin system (RAS) and catecholamine biosynthesis in the sympathetic nervous system, resulting in hypertension. And hypoxia-inducible factors (HIFs), Endotheline 1 (ET-1), and inflammatory factors are also mentioned. In addition, we will discuss the influences of SAS/IH in cardiovascular dysfunction and the relationship of microRNA (miRNA)s to regulate the key molecules in each mechanism, which has become more apparent in recent years. These findings provide insight into the pathogenesis of SAS and help in the development of future treatments.

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Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

Takeda,

Kimura,

Takasawa

2024

Life

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“…40 Nevertheless, most of these probes suffer from issues such as poor water solubility, longer response time, and shorter emission wavelength. 41,42 Moreover, only a few studies on the simultaneous detection of SO 2 and viscosity in mitochondrial dysfunction have been performed. 43–46 Lin and co-workers developed a mitochondria-targetable fluorescent probe Mito-MG for dual-response of viscosity and SO 2 .…”

Section: Introductionmentioning

confidence: 99%

A mitochondria-specific NIR fluorescence probe for dual-detection of sulfur dioxide and viscosity in living cells and mice

Sun,

Zhang,

Gao

et al. 2024

Anal. Methods

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“…These substances include superoxide anion (O 2− ), hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and peroxyl radical (OH•) ( 1 – 4 ). These oxygenated compounds are involved in numerous physiological activities that influence the state of human health and stabilize the immune system ( 5 – 7 ). Generally, a moderate level of ROS promotes cell growth, reproduction, and repair, but excessive ROS could aggravate disease symptoms and impede wound healing ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

ROS induced pyroptosis in inflammatory disease and cancer

Wang,

Wu,

Zhu

et al. 2024

Front. Immunol.

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Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.

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Recent progress of near-infrared fluorescent probes in the determination of reactive oxygen species for disease diagnosis

Cited by 10 publications

References 79 publications

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

A mitochondria-specific NIR fluorescence probe for dual-detection of sulfur dioxide and viscosity in living cells and mice

ROS induced pyroptosis in inflammatory disease and cancer

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