Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases

Feng, Leyan; Wang, Heping; Xue, Xue

doi:10.1002/adtp.201900159

Cited by 19 publications

(10 citation statements)

References 128 publications

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“…The ability to monitor stem cell movement and migration to target sites is critical. MPI can improve stem cell imaging and monitoring by determining the viability and transport of transplanted cells, and so MPI has been widely used to determine cell tracking and distribution in recent years [67].…”

Section: Targeted Imaging and Cell Trackingmentioning

confidence: 99%

Advancement of magnetic particle imaging in diagnosis and therapy

Harini,

Girigoswami,

Pallavi

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Magnetic particle imaging (MPI) has gained significant traction as an ionising radiation-free tomographic method that offers real-time imaging capabilities with enhanced sensitivity and resolutions. In this technique, magnetic nanoparticles (MNPs) are employed, particularly iron oxide nanoparticles with superparamagnetic nature, as probes within the MPI system. These MNPs enable the tracking and precise quantification of particle movement with minimal background noise. The 3D location and concentration of MNPs can provide better insights for multiple applications in vascular imaging, cell tracking, cancer cell imaging, inflammation, implant monitoring, and trauma imaging and can thus accelerate the diagnosis of disorders. The mononuclear phagocyte system provides a significant advantage, as they are involved in the spontaneous clearance of the tracers used in MPI, which readily minimise the toxic effects. Several studies have demonstrated that MPI-based functional neuroimaging is superior to other imaging modalities, providing adequate temporal resolution images with quick scan intervals. In MPI, nanoparticles are solely responsible for the source and visualisation, unlike magnetic resonance imaging (MRI), where nanoparticles were used only as supportive tracers. This review provides an overview of the principle, diagnostic, and therapeutic applications of MPI as well as the advantages and challenges MPI has over other diagnostic imaging methods in modern clinical setups.

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Section: Targeted Imaging and Cell Trackingmentioning

confidence: 99%

Advancement of magnetic particle imaging in diagnosis and therapy

Harini,

Girigoswami,

Pallavi

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…The establishment of effective therapy techniques for PD is crucial due to the success rate of present PD medication is low. [ 100,101 ] Therapy with focused ultrasound increases the BBB opening and delivers drugs into the brain for the treatment of PD. Various types of drug carriers such as liposomes, exosomes, gold, quantum dots, and polymers have enhanced the therapeutic effect, and overcome the physiological barriers.…”

Section: Therapy Modalities Of Pdmentioning

confidence: 99%

Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines

Hasan

Roy

Chang

2023

Advanced Therapeutics

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Parkinson's disease (PD) is a chronic, and highly neurodegenerative disorder with complex pathological processes. The features for neuropathological identification of PD include α‐synuclein (α‐syn) protein aggregates, oxidative stress, metal ion dyshomeostasis, neurotransmitter deficiencies, and mitochondrial dysfunction. Currently, no definite treatment paradigm can completely cure PD patients, which is increasing globally over the past few decades. The existence of the blood‐brain barrier (BBB) restricts the conventional treatment processes and makes the therapeutic delivery to the brain a bit more challenging. Therefore, developing new useful medicines for improving brain distribution is vital to overcome BBB and helping the early diagnosis and treatment of PD. In this review, the current limitations of conventional drugs are highlighted and the development of new medicines to overcome such limitations is covered. This work will provide insight into the direction for designing novel efficient nanomedicines for the early diagnosis and treatment of PD.

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“…For biomedical applications such as medication administration, bioimaging, and biosensing in CNS illnesses, a variety of inorganic NPs provide considerable efficiencies [92]. SeNPs offer a wide range of applications, including assessing and treating health-related problems that would otherwise be impossible to identify or address.…”

Section: Diagnostic Applications Of Senps In Cns Disordersmentioning

confidence: 99%

Emerging Selenium Nanoparticles for CNS Intervention

Malik¹,

AjgarAnsari²,

Ahmed³

et al. 2023

Biomedical Engineering

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Central nervous system (CNS) diseases have seriously impacted human wellness for the past few decades, specifically in developing countries, due to the unavailability of successful treatment. Due to the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier transport of drug and treatment of CNS disorders has become difficult. Nanoscale materials like Selenium nanoparticles (SeNPs) offer a possible therapeutic strategy for treating brain diseases like Alzheimer’s, Frontotemporal dementia, Amyotrophic lateral sclerosis, Epilepsy, Parkinson’s disease, and Huntington’s disease. After being functionalized with active targeting ligands, SeNPs are versatile and competent in conveying combinations of cargoes to certain targets. We shall pay close attention to the primarily targeted therapies for SeNPs in CNS diseases. The objective of this paper was to highlight new developments in the exploration of SeNP formation and their potential applications in the management of CNS diseases. Furthermore, we also discussed the mechanisms underlying management of CNS disease, several therapeutic potentials for SeNPs, and the results of their preclinical research using diverse animal models. These methods might lead to better clinical and diagnostic results.

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Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases

Cited by 19 publications

References 128 publications

Advancement of magnetic particle imaging in diagnosis and therapy

Advancement of magnetic particle imaging in diagnosis and therapy

Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines

Emerging Selenium Nanoparticles for CNS Intervention

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