Recent progress of biosensors for the detection of lung cancer markers

Chen, Shanchuan; Li, Ming-Han; Weng, Ting; Wang, Deqiang; Geng, Jianhua

doi:10.1039/d2tb02277j

Cited by 10 publications

(3 citation statements)

References 288 publications

(425 reference statements)

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“…Hence, lung cancer patients are frequently diagnosed at advanced stages, resulting in low survival rates. Early diagnosis of lung cancer significantly enhances cure rates, − reduces incidence, and prolongs patient survival. − Human Neutrophil Elastase (HNE) is a typical serine protease , that cleaves extracellular matrix components in NSCLC, accelerating lung tumor growth and promoting cancer development, thus serving as an early biomarker for NSCLC. , Calpain-2 (CAPN2), a major cysteine protease in the calcium-mediated calpain family, , plays a crucial role in tumor angiogenesis and cell migration, that overexpression of CAPN2 contributes to tumor growth in NSCLC. − Several methods for detecting HNE and CAPN2, such as enzyme-linked immunosorbent assay, electrochemical sensors, and polymerase chain reaction, have been reported, − but limited by complexity, time consumption, and high costs. − Due to the potential for misdiagnosis when only one biomarker is tested in the early stages of lung cancer, the development of simultaneous detection for two lung cancer biomarkers (CAPN2 and HNE) can significantly enhance the accuracy of early lung cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Advancing Nonsmall Cell Lung Cancer Diagnosis Accuracy via Dual Detection Fluorescent Nanoprobes

Wang,

Chang,

Ouyang

et al. 2024

Anal. Chem.

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Among the primary threats to human health worldwide, nonsmall cell lung cancer (NSCLC) remains a significant factor and is a leading cause of cancer-related deaths. Due to subtle early symptoms, NSCLC patients are diagnosed at advanced stages, resulting in low survival rates. Herein, novel Au–Se bond nanoprobes (NPs) designed for the specific detection of Calpain-2 (CAPN2) and Human Neutrophil Elastase (HNE), pivotal biomarkers in NSCLC, were developed. The NPs demonstrated exceptional specificity and sensitivity toward CAPN2 and HNE, enabling dual-color fluorescence imaging to distinguish between NSCLC cells and normal lung cells effectively. The NPs’ performance was consistent across a wide pH range (6.2 to 8.0), and it exhibited remarkable resistance to biological thiol interference, indicating its robustness in complex physiological environments. These findings suggest the nanoprobe is a promising tool for early NSCLC diagnosis, offering a novel approach for enhancing the accuracy of cancer detection.

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Section: Introductionmentioning

confidence: 99%

Advancing Nonsmall Cell Lung Cancer Diagnosis Accuracy via Dual Detection Fluorescent Nanoprobes

Wang,

Chang,

Ouyang

et al. 2024

Anal. Chem.

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“…On the other hand, it leads to an increase in the detection of false-positive changes [6,7]. Because of the need to improve techniques for lung cancer detection at an early stage, attempts have been made to use radiological artificial intelligence, liquid biopsy, biomarkers, or microRNA and others [8][9][10][11][12]. Screening tests using chest radiography and sputum culture have not been proven to cause any decline in lung cancer mortality rates [13].…”

Section: Introductionmentioning

confidence: 99%

Lung Lesions: Differential Diagnoses Beyond Cancer

Jurczak,

Romaszko-Wojtowicz,

Doboszyńska

2024

Am J Case Rep

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Unusual clinical course Background:Lung cancer is the most common malignant neoplasm diagnosed worldwide. Early diagnosis and treatment are of great importance for patient's prognosis. A wide variety of pulmonary conditions display clinical and radiological presentation similar to that of lung cancer, and the awareness of their existence can help in making correct diagnoses. Case Reports:This article presents a description of 4 patients with an insidious type of lesions mimicking pulmonary carcinomas. The first patient was referred to Department with a tumor-like lesion in the right lung. After CT of the chest and core-needle biopsy, the lesion turned out to be an ectopic thyroid tissue. The second patient reported a dry cough and weight loss. A lung nodule mass was revealed in chest CT and the patient was diagnosed with pulmonary tuberculoma. The remaining 2 patients, despite the suspicion of lung cancer, were subsequently diagnosed with a post-traumatic pleural hematoma and diffuse large B cell lymphoma. Conclusions:Low-dose computed tomography of the chest plays a significant role in the diagnosis of newly detected lesions in the lungs. However, due to the similarity of the image of cancer to that of other diseases, the ultimate diagnosis should be based on the interpretation of full imaging diagnostic tests, clinical presentation, and histopathological examination of the material obtained from the lesion. Analysis of cases enables us to expand our understanding of the diseases that need to be considered in differential diagnosis of a patient with a detected tumor-like lesion in the lungs.

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“…However, electrochemistry is affected by long detection times, which can compromise the accuracy of experimental results. 6–9 Therefore, there is an urgent need to develop a platform for simultaneous detection of multiple targets, enabling early diagnosis and timely subtyping of lung cancer, which can facilitate the administration of appropriate treatments and improve patient survival rates. 10,11…”

mentioning

confidence: 99%