Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth

Zhang, Jiarui; Chen, Ruosi; Wen, Lihong; Fan, Zhexiang; Guo, Yilong; Miao, Yong

doi:10.3389/fcell.2021.736738

Cited by 6 publications

(5 citation statements)

References 61 publications

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“…[24] It has been previously reported that mediators secreted by the nervous system play an important role in hair follicle's growth. [36] Our results also suggest a possible correlation between the somatic nervous system and hair follicle development. Several studies have found that the herpes simplex virus type 1 can infect skin neurons, which could result in release of cytokines and neuropeptides and affect the neural function and immune system.…”

Section: Discussionsupporting

confidence: 57%

Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection

Liu

Gao

et al. 2021

Advanced Science

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Coronavirus disease 2019 (COVID‐19) patients with impact on skin and hair loss are reported. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is detected in the skin of some patients; however, the detailed pathological features of skin tissues from patients infected with SARS‐CoV‐2 at a molecular level are limited. Especially, the ability of SARS‐CoV‐2 to infect skin cells and impact their function is not well understood. A proteome map of COVID‐19 skin is established here and the susceptibility of human‐induced pluripotent stem cell (hiPSC)‐derived skin organoids with hair follicles and nervous system is investigated, to SARS‐CoV‐2 infection. It is shown that KRT17+ hair follicles can be infected by SARS‐CoV‐2 and are associated with the impaired development of hair follicles and epidermis. Different types of nervous system cells are also found to be infected, which can lead to neuron death. Findings from the present work provide evidence for the association between COVID‐19 and hair loss. hiPSC‐derived skin organoids are also presented as an experimental model which can be used to investigate the susceptibility of skin cells to SARS‐CoV‐2 infection and can help identify various pathological mechanisms and drug screening strategies.

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Section: Discussionsupporting

confidence: 57%

Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection

Liu

Gao

et al. 2021

Advanced Science

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“…Since the crucial role of Merkel cells in touch sensation has been elucidated [39], this evidence showed the ability of the HF skin organoids to mimic the sensory function of in vivo tissues. Additionally, previous research has reported that signaling from the nervous system promotes HF development through the secretion of mediators [15,40]. The presence of neuron cells in our skin organoids is consistent with previous findings, suggesting that HF growth could be greatly facilitated.…”

Section: O Discussionsupporting

confidence: 92%

Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids

et al. 2022

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Regenerating hair follicles (HFs) is a critical medical need for patients who suffer from serious hair loss. To generate equivalent hair-bearing skin systems that could mimic the complexity of native tissues with pluripotent stem cells, floating culture has been employed as a standard method; however, it is still necessary to improve limitations such as the heterogeneity of organoids and the difficulty of handling them, which increases during long-term culture. Here, we devise a floating-adherent combinatory culture system to establish skin HF organoids from human-induced pluripotent stem cells (hiPSCs). Specifically, embryoid bodies were generated in a free-floating environment, followed by the induction process, which occurred in adherent conditions. With our approach, hair germ-like buds were shown to protrude and extend faster. After 100 days of culture, mature cystic skin organoids stratified to form the epidermis, dermis, and outer root sheath, as evident from quantitative polymerase chain reaction and immunohistochemistry analysis. Dermal condensate cells (Sox2+, PDGFRα+, P75+), which are the precursors of HFs, were detected together with HF stem cells (NFATC1+, LGR5+), putative bulge stem cells (LHX2+, KRT15+) and melanocytes (PMEL+). Notably, our constructed HFs could recapitulate the sensory function of native tissues, as illustrated by the formation of a network of sensory neurons and Schwann cells connecting towards HF cells and epidermal progenitors. In summary, our results demonstrate a new protocol for the simplified and efficient induction of skin HFs from hiPSCs, thereby contributing to research on optimizing HF growth and investigating novel therapeutic strategies to treat alopecia.

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“…The age-dependent changes in the lipid content of the nail plates are the principal factor responsible for the differences in structure and performance in general of the nails that occur with advanced age. These changes occur as a result of the natural process of aging [41]. Age-related macular degeneration has a major negative influence on quality of life due to vision impairment [42].…”

Section: Discussionmentioning

confidence: 99%

Change in physical and mental health due to aging: future perspective

2023

FEM

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Aims: By addressing these research issues and examining the findings of the pertinent studies, this systematic review aims to provide a thorough understanding of the changes in physical and mental health that are related with aging as well as the significant factors that contribute to these changes. This evaluation will also look into potential new treatments and technological advancements that could improve elderly people's health. The results of this work will offer crucial new perspectives on aging research and therapeutic practice in the future. Methodology: "Aging", "physical health", "mental health", "wellbeing", "lifestyle interventions", "age-related health problems", "literature evaluation", "future perspectives", "key factors", "potential new interventions", and "health outcomes" were used to search Medline, pubmed, and Google Scholar. Successful search. Data analysis began with selecting relevant details. Second, the data was compiled into a table, followed by study conclusions. After reviewing each article, the overarching idea that best proves the study issue's relevance was chosen. Results: The literature display includes several physiological and physical effects of aging and research and reference information. Aging affects skin, hair, nails, vision, digestion, bone density, muscle flexibility, and heart disease risk. Aging causes anxiety, memory loss, and executive dysfunction Scientific Novelty: Potentially effective innovative measures to enhance senior citizens' health a study of the key elements influencing how physical and mental health vary as people age Conclusion: The systematic review gave a thorough grasp of the alterations in physical and mental health brought on by aging, as well as the main causes of these alterations. The review also uncovered potential novel therapeutic approaches and scientific developments that might enhance the health of senior citizens. This work emphasizes the necessity of ongoing study and therapeutic application to improve older individuals' quality of life.

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Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth

Cited by 6 publications

References 61 publications

Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection

Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection

Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids

Change in physical and mental health due to aging: future perspective

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