“…On the other hand, the proximity of the reactive amino and mercapto groups in these triazole derivatives could be exploited in ring closure reactions leading to fused heterocycles. For example, reaction of 4-amino-3-mercapto-1,2,4-triazoles with a variety of reagents has been extensively employed for the generation of triazolothiadiazines, 27 whose interesting biological activities have been well documented. 28 The present contribution aims at expanding the series of previously reported derivatives of 5-(thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4triazole-3-thione 29,30 by preparing several azomethines and triazolothiadiazines derived from the aforementioned scaffold featuring an amino group at position 4 of the triazole ring.…”