Recent progress in the structural modification of chitosan for applications in diversified biomedical fields

Mittal, Hemant; Ray, Suprakas Sinha; Kaith, Balbir Singh; Bhatia, Jaspreet Kaur; Sukriti,; Sharma, J. N.; Alhassan, Saeed M.

doi:10.1016/j.eurpolymj.2018.10.013

Cited by 159 publications

(60 citation statements)

References 478 publications

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“…[185,186]. The use of nanoparticles is not new and current papers deal with specific derivatives such as carboxymethyl CS (CMCS), which are soluble Very recently, Mittal et al [174] published a deep and comprehensive review that scientist readers should adress to fully understand the progress of CS chemistry for use in biomedical fields, as well as the paper of Laroche et al [4], which highlighted the need for an integral approach to comprehend all the potential of CS and its derivatives. Additionnaly, Khan et al [175] detailed in their review the implications of the molecular diversity of chitin, CS, and some derivatives.…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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“…CS also has colloidal stability, a tunable membrane, and the ability to encapsulate or integrate a broad range of drugs. CS-based matrices have been effectively used for the controlled delivery of many biomolecules, ranging from small drug molecules to biopolymers [37]. DOX HCl was loaded onto a nanocarrier made of CS-poly(methacrylic acid) shell and nFe 3 O 4 through electrostatic interactions and strong H bonds.…”

Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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“…The deacetylation process of chitin to chitosan, which could be accomplished either by chemical, or enzymatic hydrolyses, generally involves removal of acetyl (CH 3 C ¼ O-) groups resulting in the formation of amino (NH 2 -) groups, i.e. the formation of copolymers of N-acetylglucosamines and glucosamines ( Figure 1) [27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

The 21st century revival of chitosan in service to bio-organic chemistry

Yaneva

Ivanova

Nikolova

et al. 2020

Biotechnology & Biotechnological Equipment

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The design and synthesis of biopolymer nano-and micro-formulations are a new trend with growing priority in scientific research and development in the fields of biomedicine, bioorganic/ medicinal chemistry, pharmaceutics, agrochemistry and food industry. This incorporates a vast variety of improved and newly-developed analytical and physico-chemical techniques for green and efficient synthesis. The scope of the present review was to outline the recent advances in the methods for design of novel chitosan micro-and nano-carriers and transporters. Special emphasis is laid on their functionalities and capacity for encapsulation of natural bioactive compounds and controlled in vitro/in vivo release in various biological/physiological media. Expectations for the application of chitosan formulations and chitosan-based hybrid systems are progressively increasing as the knowledge regarding their physical, chemical and biological properties constantly expands. Thus, this review proposes insights on the objective assessment of the capacity, applicability and versatility of newly-designed chitosan-based hybrid systems. A detailed integrative approach, which incorporates the innovative scientific achievements based on complex novel, precise and reliable analytical procedures and methods for qualitative and quantitative morphological, structural, spectral, chemical and biochemical analyses of the bioprecursors and the designed chitosan-carrier micro/nano-hybrid systems, is applied. Sustainable knowledge on the mechanism and methods of natural bioactive substances encapsulation and in vitro/in vivo release is reviewed and discussed.

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Recent progress in the structural modification of chitosan for applications in diversified biomedical fields

Cited by 159 publications

References 478 publications

Modification of Chitosan for the Generation of Functional Derivatives

Modification of Chitosan for the Generation of Functional Derivatives

Polymers and Polymer Nanocomposites for Cancer Therapy

The 21st century revival of chitosan in service to bio-organic chemistry

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