Recent Progress in the Chemistry and Biology of Paclitaxel (TaxolTM) and Related Taxanes

Efficient Synthesis of α-Quaternary α-Hydroxy-β-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions

“…α-Hydroxy-β-amino acids and their congeners are important building blocks in natural products and biologically active agents . Representative examples are taxoid-based anticancer agents, such as paclitaxel (Taxol), docetaxel, and cabazitaxel, all of which carry (2 R , 3 S )-3-phenylisoserine on C-13 . The success of these anticancer agents has stimulated tremendous efforts to develop efficient methods to synthesize this side chain .…”