Eur. J. Chem. volume 3, issue 2, P258-266 2012 DOI: 10.5155/eurjchem.3.2.258-266.536
Cai Xiao-Hua, Guo Hui, Xie Bing
Abstract: KEYWORDSThe asymmetric Mannich reaction is one of the most useful carbon-carbon bond forming reactions for the synthesis of chiral molecules containing nitrogen. The resulting β-amino carbonyl compounds are valuable synthons in the preparation of many natural products with useful biological properties. In recent years, asymmetric Mannich processes have increasingly been reported and used in a rapidly growing number of applications. This review provides an overview of the recent history of the applications of various catalytic systems in asymmetric Mannich reaction, including metal-based asymmetric organocatalysis, asymmetric organocatalysis, other chiral catalysis and no chiral catalysis systems. Chiral amine catalysis Chiral Bronsted acid Asymmetric organocatalysis Metal-based organocatalysis Asymmetric Mannich reaction Diastereo-and enantioselective
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