Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review

Ghasemian, Motaleb; Kazeminava, Fahimeh; Naseri, Ayman; Abbaszadeh, Mahmoud; Kafil, Hossein Samadi; Ahmadian, Zainab

doi:10.1016/j.biopha.2023.115328

Cited by 10 publications

(4 citation statements)

References 200 publications

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“…Due to these versatile properties, it has been observed that TA provides promising clinical results against myocardial infarction, 21 renal failure, 22,23 and cancer 24 . TA is also the focus of many studies in terms of its restorative effects on HCC tumor progression 25,26 …”

Section: Introductionmentioning

confidence: 99%

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Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

Tosun,

Karadas,

Ceylan

2024

Cancer Medicine

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BackgroundHepatocellular carcinoma (HCC) is the most common type of primary liver cancer, occurring mostly in individuals with chronic liver disease, but biomarkers for therapeutic diagnosis and prognosis are lacking. This study aimed to investigate the possible effect of the common food additive monosodium glutamate (MSG) and tannic acid (TA), a phenolic compound, on the key molecular actors responsible for HCC development.MethodsEight HCC‐related public microarray datasets (GSE84005, GSE14520, GSE25097, GSE57958, GSE22058, GSE84402, GSE54238, and GSE36376) were extracted from the gene expression omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). To make sense of the identified biological data and to identify hub genes, protein–protein interaction (PPI) network and enrichment analysis were performed. The mRNA expression profiles of the identified hub genes, expression changes in different stages of HCC, and their prognostic significances in HCC were determined using GEPIA, UALCAN, and Kaplan–Meier Plotter databases, respectively. Finally, mRNA expression changes of identified hub genes in the liver tissues of rats treated with MSG and TA were measured by the quantitative real‐time PCR (qPCR) method.ResultsTwo up‐regulated (AURKA and CCNB2) and two down‐regulated (F9 and CYP2E1) genes were identified between the HCC tumor and adjacent non‐tumor liver tissue samples. qPCR results showed that the mRNA expression of up‐regulated DEGs involved in HCC development increased significantly in rat liver tissues exposed to MSG, while this increase was remarkably suppressed by TA treatment. It was observed that the mRNA expressions of down‐regulated DEGs involved in HCC development decreased markedly in the presence of MSG, while this decrease was alleviated with TA.ConclusionOur results provide new insights into pivotal molecular candidates that should be focused on in future in vivo and in vitro HCC research. Moreover, MSG may play a crucial role in HCC development and progression and TA may be used as a favorable restorative agent in HCC.

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Section: Introductionmentioning

confidence: 99%

“… 24 TA is also the focus of many studies in terms of its restorative effects on HCC tumor progression. 25 , 26 …”

Section: Introductionmentioning

confidence: 99%

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

Tosun,

Karadas,

Ceylan

2024

Cancer Medicine

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“…14 TA has shown many beneficial biological characteristics that are antioxidant, antibacterial, anticarcinogenic, and anti-inflammatory. 15,16 TA is recognized as a highly beneficial material component for orthopedic transplantation since it can suppress osteoclast activities and immobilize Sr (II) on Ti surface to enhance bone cell regeneration. 17 drug-releasing hydrogel after injection, providing a controlled release up to 25 days, 18 which is suggested to be sufficiently long for more proficient treatment of cancer cells.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The benefits of such multiple linkages include helping to cross-link polymers to construct a hydrogel as well as creating gel adhesion to a substrate, thereby forming a hydrogel coating layer that can be fine-tuned for different medical requirements. , TA has received more attention in recent years for drug-releasing biomaterial development because of its strong intermolecular linkages that can last up to 14 days in a wet environment, while the molecules essentially degrade by hydrolysis to noncytotoxic residues . TA has shown many beneficial biological characteristics that are antioxidant, antibacterial, anticarcinogenic, and anti-inflammatory. , TA is recognized as a highly beneficial material component for orthopedic transplantation since it can suppress osteoclast activities and immobilize Sr (II) on Ti surface to enhance bone cell regeneration . Our previous research demonstrates that TA can cross-link polyethylene glycol (PEG) to rapidly form a drug-releasing hydrogel after injection, providing a controlled release up to 25 days, which is suggested to be sufficiently long for more proficient treatment of cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Drug-Releasing Tannic Acid-Mediated Adhesive PEG Hydrogel for Porous Titanium Implants

Bubpamala,

Promoppatum,

Pholpabu

2023

ACS Omega

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Porous titanium implants are commonly utilized for orthopedic surgery because they can mimic the mechanical properties and porous structure of human bone. However, the bioinertness of titanium (Ti) has been reported to obstruct biointegration processes, resulting in slower bone repair. Here, we propose a localized drug delivery system on Ti surfaces using adhesive hydrogel to enhance biological-Ti interactions. The hydrogel was fabricated from polyethylene glycol (PEG), which was cross-linked by the complex of tannic acid (TA) and 1,4-phenylenediboronic acid (PDBA) and stabilized by bovine serum albumin (BSA). The hydrogel was formed and attached to a Ti plate to investigate stability, biodegradability, controlled drug release, and biocompatibility. The stability and biodegradability of the hydrogel could be tuned by adjusting the concentrations of BSA and TA. The hydrogel lasted and remained adhered to the Ti surface after being submerged in PBS for at least 15 days. The controlled release of strontium ranelate (SrRan) and the release mechanism depended on the amount of TA since it was found to govern the hydrogel integrity and pore size. Additionally, in vitro biocompatibility was validated using L929 fibroblast and MC3T3-E1 osteoblast cells that showed greater than 70% viability. The adhesive hydrogel was further studied by injecting it into a 3D-printed Ti-scaffold that contained a porous structure mimicking natural human bone. The hydrogel completely filled and adhered to the inner porous structure of the scaffold. The biodegradation and drug release of the hydrogel in the scaffold occurred at a slower rate, suggesting sustainable drug release that is suitable for bone cell regeneration. The overall results in biodegradability, controlled drug release, and biocompatibility demonstrate the great potential of the drug-releasing TA-mediated adhesive PEG hydrogel as a Ti-enhancing biomaterial that supports osseointegration.

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Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review

Cited by 10 publications

References 200 publications

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

Drug-Releasing Tannic Acid-Mediated Adhesive PEG Hydrogel for Porous Titanium Implants

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

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