Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review
Mustapha Suleiman,
Faisal A. Almalki,
Taibi Ben Hadda
et al.
Abstract:The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, but due to the severe side effects and multidrug resistance spawning from the treatment of HIV/AIDS using highly active retroviral therapy (HAART), it has become imperative to design and synthesise novel anti-HIV agents. Literature has shown that natural sources, particularly … Show more
The stoichiometric reaction between coumarin-substituted N-heterocyclic carbene (NHC) precursors and Pd(OAc)2, in the presence of an external base, yielded imidazole-fused pentacyclic pyrrolo[3,4-c]coumarin derivatives.
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