Recent progress in sustained/controlled oral delivery of captopril: an overview

Nur, Abubakr O.; Zhang, Jun S

doi:10.1016/s0378-5173(99)00362-2

Cited by 58 publications

(29 citation statements)

References 30 publications

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“…The drug is freely soluble in water (125-160 mg/ml, at pH 1.9) with pKa of 3.64 at 25°C and its partition coefficient is pH-dependent (11,12). It has a relatively short elimination half-life in plasma (1-3 h) and low oral bioavailability (% 60-75) (1,(13)(14)(15). For these reasons, by applying this drug as a transdermal therapeutic system, dosing time intervals will be expanded so that patient compliance will be arised and side effects will be minimised.…”

Section: Introductionmentioning

confidence: 99%

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Kerımoğlu¹,

Şahbaz²,

Şehirli³

et al. 2015

mpj

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The objective of this study was to evaluate the mechanical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their adhesiveness and bioadhesiveness by using texture analyser. These optimum formulations were chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Results indicated that the mechanical properties of the formulations were suitable to be used as a transdermal patch.

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Section: Introductionmentioning

confidence: 99%

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Kerımoğlu¹,

Şahbaz²,

Şehirli³

et al. 2015

mpj

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“…prolina, é um potente inibidor da enzima conversora de angiotensina (ECA) por via oral, sendo indicado no tratamento da hipertensão arterial e insuficiência cardíaca congestiva (Brogden et al, 1988;Garrison, Peach, 1991;Nur, Zhang, 2000). É suscetível de sofrer degradação oxidativa, especialmente quando em solução aquosa (Connors et al, 1986;Taketomo et al, 1990;Martindale, 1993;Trissel, 2000).…”

unclassified

Estudo termoanalítico de comprimidos revestidos contendo captopril através de termogravimetria (TG) e calorimetria exploratória diferencial (DSC)

Bazzo¹,

Silva²

2005

Rev. Bras. Cienc. Farm.

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“…CAP as highly water soluble drug is most stable at acidic condition and unstable in intestine or pH increases with degradation reaction. These indicate a promising potential as gastroretentive drug delivery system to improve the bioavailability and prolong the drug release (Nur and Zhang, 2000).…”

Section: Introductionmentioning

confidence: 94%

Optimization and Acessing the Influence of Xanthan Gum, Effervescent Components and Hardness on Floatation Behavior and Drug Release of Gastro-Floating Captopril Tablet

Choiri

Sulaiman

Kuncahyo

2014

Indonesian J. Pharm.

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This research purposed to optimize, investigate and evaluate the influence of xanthan gum, sodium bicarbonate-citric acid as effervescent components and hardness on floatation behavior and drug release of gastro-floating captopril tablet with floating system. A 2 3 full factorial design (8 runs) was applied to optimize the floating captopril tablet using xanthan gum (X 1 ), ratio of effervescent components (X 2 ) and hardness (X 3 ) as independent variables. Optimum area was determined by superimposed contour plot of floating lag time (Y 1 ), cumulative drug release at 60min (Q 60 ) (Y 2 ) and drug release constant rate (Y 3 ) using Design Expert ® software. Xanthan gum, effervescent components and hardness were affected the floatation behavior and drug release. Hardness was the most dominant factor affected the floatation behavior and drug release. Based on superimposed contour plot, the optimum area was in range of xanthan gum 58-100mg, sodium bicarbonate 45-63mg, citric acid 7-25mg and hardness at 70-98N.

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Recent progress in sustained/controlled oral delivery of captopril: an overview

Cited by 58 publications

References 30 publications

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Estudo termoanalítico de comprimidos revestidos contendo captopril através de termogravimetria (TG) e calorimetria exploratória diferencial (DSC)

Optimization and Acessing the Influence of Xanthan Gum, Effervescent Components and Hardness on Floatation Behavior and Drug Release of Gastro-Floating Captopril Tablet

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