Recent Progress in Stem Cell Therapy for Diabetic Nephropathy

Liu, Yang; Tang, Sydney C.W.

doi:10.1159/000441913

Cited by 31 publications

(34 citation statements)

References 85 publications

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“…These contrasting results could be explained by the differences in the longterm and short-term exposures to pro-inflammatory conditions. For example, in a long-term exposure study, stem cells from the apical papilla demonstrated inhibition of osteogenesis when exposed to proinflammatory cytokines (TNF-α and interleukin 1 beta), while the cytokines induced mineralization in the short-term culture [101]. In view of all the data presented here, we can infer that BPA acts on MSCs exhibiting inconsistent behavior and it is also clear that short and longterm exposure studies differ significantly.…”

Section: Osteogenic Differentiationmentioning

confidence: 65%

“…MSCs have gained attention in the field of regenerative medicine because they can potentially modulate numerous incurable diseases [102]. Currently, there are 333 published studies describing the use of MSCs in clinical trials, addressing the prospective therapies for diseases such as cardiovascular disease [103], diabetic nephropathy [101], diverse brain injuries (including stroke, neural trauma, and heatstroke) [104] and lung injury [105]. These cells are widely used because of their multiple biological functions, including multi-lineage differentiation, their ability to promote tissue-repair, as well as their anti-inflammatory and immunosuppressive effects.…”

Section: Discussionmentioning

confidence: 99%

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Bisphenol a and mesenchymal stem cells: Recent insights

et al. 2018

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Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem cells (ASCs) are often effective and safe, and have been used in preclinical and clinical studies for both autologous and allogeneic transplantation. The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs provides an important alternative therapeutic solution for the treatment of many diseases. However, it is necessary to have control of the cell manipulation process prior to their use. Exposure of humans to the endocrine disruptor bisphenol A (BPA) has been associated with increased weight and obesity, but the mechanisms by which BPA increases adipose tissue in humans remains to be determined. BPA has been classified as a potent endocrine-disrupting chemical that interferes with adipogenesis. Currently, few studies have reported the effect of BPA on the integrity and capacity for differentiation of MSCs. Thus, this review aims to present, for the first time, a current survey and a discussion of the effects of BPA action on MSCs.

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Section: Osteogenic Differentiationmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Bisphenol a and mesenchymal stem cells: Recent insights

et al. 2018

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“…MSCs have been popularly used in cell therapy, although their clinical usefulness remains restricted. MSCs of various donors are heterogeneous and in vitro cell passages and culture conditions directly affect the cell phenotype (Kretlow et al, 2008; Liu and Tang, 2015; Turinetto et al, 2016). In addition, cellular senescence significantly impairs the potential for MSC proliferation and differentiation (Turinetto et al, 2016).…”

Section: Challenges Of Using Mscs In Cell Therapymentioning

confidence: 99%

Mesenchymal stromal cell‐derived extracellular vesicles as cell‐free biologics for the ex vivo expansion of hematopoietic stem cells

Budgude

Kale

Vaidya

2020

Cell Biology International

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Hematopoietic stem cell transplantation (HSCT) is the ultimate choice of treatment for patients with hematological diseases and cancer. The success of HSCT is critically dependent on the number and engraftment efficiency of the transplanted donor hematopoietic stem cells (HSCs). Various studies show that bone marrow-derived mesenchymal stromal cells (MSCs) support hematopoiesis and also promote ex vivo expansion of HSCs. MSCs exert their therapeutic effect through paracrine activity, partially mediated through extracellular vesicles (EVs). Although the physiological function of EVs is not fully understood, inspiring findings indicate that MSC-derived EVs can reiterate the hematopoiesis, supporting the ability of MSCs by transferring their cargo containing proteins, lipids, and nucleic acids to the HSCs. The activation state of the MSCs or the signaling mechanism that prevails in them also defines the composition of their EVs, thereby influencing the fate of HSCs. Modulating or preconditioning MSCs to achieve a specific composition of the EV cargo for the ex vivo expansion of HSCs is, therefore, a promising strategy that can overcome several challenges associated with the use of naïve/unprimed MSCs. This review aims to speculate upon the potential role of preconditioned/primed MSC-derived EVs as "cell-free biologics," as a novel strategy for expanding HSCs in vitro.

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“…Microscopic changes involve the thickening of the tubular basement membrane (TBM) and glomerular basement membrane (GBM), and mesangial proliferation, glomerulotubular junction abnormalities (GTJA) and arteriosclerosis. And for the ultramicroscopic changes, podocyte effacement and decrease in its density appear to be the centerpiece of DN pathogenesis [30]. Consisting of the pivotal workload of dialysis centers throughout the world, DN is often featured by glomerulosclerosis, tubulointerstitial fibrosis as well as tubular atrophy [31], which starts with albuminuria, which can progress from microalbuminuria to macroalbuminuria [32].…”

Section: Dn and Podocytementioning

confidence: 99%

The Effect of Endoplasmic Reticulum Stress on Podocyte Apoptosis in Diabetic Nephropathy

Ren¹

2020

Molecular Biology &Amp; Nanomedicine

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Diabetic nephropathy (DN) has already become the leading reason for the end-stage renal disease throughout the world. As current therapeutic strategy for progression of DN remained only moderately successful, the underlying mechanisms remain less understood. Endoplasmic reticulum (ER), mitochondria, and death receptor could activate apoptotic pathways, such as caspase-independent pathways. Accumulating evidence indicated that ER stress played a major role in the development and progression of DN. And the aberrant activation of ER stress induced both the inflammation and cellular apoptosis, and modulate the signaling of protective processes including the autophagy. In addition, a growing number of evidences suggested that glomerular podocyte was the key player in DN, and yet the mechanism how ER signaling affected the podocyte apoptosis remained to be well-understood. Because podocytes are terminally differentiated epithelial cells in lack of the capability to proliferate, thus the loss of podocytes is a significant biomarker of progressive kidney diseases, including DN. Hence, the podocyte apoptosis is to be of great significance for the DN treatment. In this review, we summarized relevant apoptotic pathways involved in excessive ER stress-induced apoptosis.

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Recent Progress in Stem Cell Therapy for Diabetic Nephropathy

Cited by 31 publications

References 85 publications

Bisphenol a and mesenchymal stem cells: Recent insights

Bisphenol a and mesenchymal stem cells: Recent insights

Mesenchymal stromal cell‐derived extracellular vesicles as cell‐free biologics for the ex vivo expansion of hematopoietic stem cells

The Effect of Endoplasmic Reticulum Stress on Podocyte Apoptosis in Diabetic Nephropathy

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