Recent progress in research on Tripterygium: A male antifertility plant

Involvement of Mitochondrial Pathway in Triptolide-Induced Cytotoxicity in Human Normal Liver L-02 Cells

“…[2][3][4] The ethanol extract, ethyl acetate extract, and other extracts of TWHf containing triptolide have been used for the treatment of rheumatoid arthritis and autoimmune diseases clinically and triptolide was deemed to account for the immunosuppressive activity of the extracts. [5][6][7] However, triptolide has severe toxicities on digestive, urogenital, and blood circulatory systems, 8,9) which have largely limited its clinical application.…”

Prophylactic effects of triptolide on colon cancer development in azoxymethane/dextran sulfate sodiuminduced mouse model

“…For example, triptolide, which was isolated during the phytochemical investigation of Tripterygium wilfordii Hook F, is a complex diterpenoid molecule [16][17][18]. Biological investigations of triptolide have revealed its potential as a suppressor of the immune system, an anticancer agent, and a contraceptive [16][17][18]. Triptolide treatment of cancer cells induces apoptosis via cytochrome c release, damages mitochondria, and suppresses antiapoptotic protein expression [19].…”

Inhibition of β‑catenin protein expression by triptolide affects self-renewal of liver cancer stem cells

“…Latter on it was found that triptolide exhibits immunosuppressor, anti-cancer, and contraceptive activities (Zhen et al, 1995;Tengchaisri et al, 1998;Hachida et al, 1999). It was also reported to induce apoptosis through cytochrome c release and by reducing the anti-apoptotic proteins expression (Carter et al, 2006).…”