Recent progress in rational design of fluorescent probes for Fe2+ and bioapplication

Lu, Yao; Ruan, Guotong; Du, Wei; Li, Jie; Yang, Naidi; Wu, Qiong; Lu, Li; Zhang, Chengwu; Li, Lin

doi:10.1016/j.dyepig.2021.109337

Cited by 18 publications

(18 citation statements)

References 99 publications

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“…The ferroptosis process, usually accompanied by extensive iron accumulation and lipid peroxidation, increased mitochondrial membrane density and mitochondria atrophy . Doxorubicin is a chemotherapeutic agent that induces cardiotoxicity through mitochondria-dependent ferroptosis, which could be attenuated by an Fe 2+ chelator-targeting mitochondria . Since then, scientists have paid much attention to ferroptosis. − In view of these, the accurate, quantitative, and visual detection of • OH and Fe 2+ in the human body is a great significance for the protection and treatment of diseases and tumors …”

Section: Introductionmentioning

confidence: 99%

C-CdTe Quantum Dots as Dual-Wavelength Fluorescence and Colorimetric Probes to Detect Hydrogen Peroxide, Hydroxyl Radicals, and Iron(II) in Serum

Zhou

Zhang

et al. 2022

ACS Appl. Nano Mater.

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The Fenton reaction has been widely utilized in tumor therapy and ferroptosis immunity in recent years. Therefore, the detection of hydrogen peroxide (H2O2), hydroxyl radicals (•OH), and iron(II) (Fe2+) in serum is urgently in need. A multifunctional combined carbon–CdTe quantum dots (C-CdTeQDs) probe is first established for the quick succession determination of H2O2 and Fe2+ in goat serum and human urine based on the fluorescence and colorimetric method. The double-emission fluorescence detection is performed by breaking the thioglycolic acid bond on the surface of CdTeQDs by H2O2 to quench the fluorescence at 594 nm. After the condition optimization, the fluorescence intensity is linearly related to H2O2 concentration, with a limit of detection of 58 nM. The colorimetric detection of •OH and Fe2+ concentrations is then continued by the Fenton reaction and the complexation reaction. Among them, the detection range of •OH is 0.01–0.1 μM with the limit of detection of 8 nM. Several advantages such as versatility, convenience, high selectivity, and sensitivity of the C-CdTeQDs probe indicated that it has great potential for the determination of H2O2 and Fe2+ in serum.

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Section: Introductionmentioning

confidence: 99%

C-CdTe Quantum Dots as Dual-Wavelength Fluorescence and Colorimetric Probes to Detect Hydrogen Peroxide, Hydroxyl Radicals, and Iron(II) in Serum

Zhou

Zhang

et al. 2022

ACS Appl. Nano Mater.

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“…In particular, structure-property relationships help with the understanding of the materials’ characteristics, thus improving their performance. Especially in the field of analytics, stimuli responsive molecules are of great interest due to their ability to selectively and reversibly bind an analyte, while exhibiting significant and detectable changes of their molecular electronic properties, e.g., color, luminescence, or redox potentials [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Analytes that can be detected by chemosensors are manifold, ranging from biologically relevant anions and cations to protons, gases and even small neutral molecules [ 50 , 51 , 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Amphipolar, Amphiphilic 2,4-diarylpyrano[2,3-b]indoles as Turn-ON Luminophores in Acidic and Basic Media

et al. 2022

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A versatile amphiphilic pyrano[2,3-b]indole for halochromic turn-ON luminescence in acidic or basic media is accessed by an insertion-coupling-cycloisomerization and adjusting solubilizing and phenolic functionalities. While almost non-emissive in neutral solutions, treatment with acids or bases like trifluoroacetic acid (TFA) or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) reveals distinct luminescence at wavelengths of 540 nm or 630 nm in propan-2-ol, respectively. Turn-ON emission can be detected at pH values as mild as pH = 5.31 or 8.70. Quantum yields in propan-2-ol are substantial for protonated (Φf = 0.058) and deprotonated (Φf = 0.059) species. Photometrically, pKa1 of 3.5 and pKa2 of 10.5 were determined in propan-2-ol. With lipophilic polyether sidechains and hydrophilic protonation and deprotonation sites the molecule can be regarded as amphipolar, which results in good solubility properties for different organic solvents. In aqueous media, an organic co-solvent like propan-2-ol (35%) or tetrahydrofuran (25%) is needed, and the solution can be diluted with pure water without precipitation of the compound. At higher concentrations of water, a turbid solution is formed, which indicates the formation of micellar structures or clusters. With dynamic light scattering we could show that these clusters increase in size with increasing water content.

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“…Compared with other analysis methods, fluorescence-based detection has the advantages of convenient, real-time, and spatiotemporal optical readouts, and fluorescent probes for LIP, which were only available in recent years, have become powerful tools for exploring iron homeostasis and regulation in physiological and pathological conditions. 11,12…”

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confidence: 99%

“…1a) often give turn-off fluorescence responses, which may limit their use in biological systems, and reactivity-based probes have become the mainstream of fluorescent probes for Fe 2+ . 12 So far, Fe 2+ -chelation induced oxidative cleavage of C–O bonds, 18 and reductions of N -oxide, 19–21 endoperoxide, 22 TEMPO, 23 and N -aryl hydroxylamine acetate 16 have been adopted for sensing Fe 2+ (Fig. 1b and d).…”

mentioning

confidence: 99%

“…1b and d). However, there are one or more limitations associated with current probes such as slow reaction rate, 12 and potential interference from other metal ions or radicals including Co 2+ , 18 Cu + , 22 Cu 2+ , 16 and ·OH. 23 Therefore, the development of fluorescent probes for Fe 2+ with fast response, excellent selectivity, and high sensitivity is still highly desirable in this field.…”

mentioning

confidence: 99%

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A PET-based fluorescent probe for monitoring labile Fe(ii) pools in macrophage activations and ferroptosis

Xing

et al. 2022

Chem. Commun.

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Recent progress in rational design of fluorescent probes for Fe2+ and bioapplication

Cited by 18 publications

References 99 publications

C-CdTe Quantum Dots as Dual-Wavelength Fluorescence and Colorimetric Probes to Detect Hydrogen Peroxide, Hydroxyl Radicals, and Iron(II) in Serum

C-CdTe Quantum Dots as Dual-Wavelength Fluorescence and Colorimetric Probes to Detect Hydrogen Peroxide, Hydroxyl Radicals, and Iron(II) in Serum

Amphipolar, Amphiphilic 2,4-diarylpyrano[2,3-b]indoles as Turn-ON Luminophores in Acidic and Basic Media

A PET-based fluorescent probe for monitoring labile Fe(ii) pools in macrophage activations and ferroptosis

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