Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

Abstract

Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass...

Applications and prospects of microneedles in tumor drug delivery

“…Soluble materials include HA, 104,105 PVP, 106,107 PVA, 107 and phthalate cellulose. 68 Biodegradable materials include PLA, PLGA, 108–110 GelMA, 111 HAMA, 69,112 CMCSMA, CMCMA, DexMA, and SilMA (Table 2).…”

Enhancing cell-scale performance via sustained release of the varicella-zoster virus antigen from a microneedle patch under simulated microgravity

“…[36][37][38] Conventional biodegradable microneedles mainly fabricated from poly(lactic-co-glycolic acid) and its derivatives can prolong the release time of drugs to a certain extent. [39][40][41][42] Nevertheless, they can only maintain the release progress of the loaded drug for a few days. There is still a lack of a durable VZV vaccine delivery system that can directly and further prolong the vaccine efficacy and subsequent immune responses with convenience and compliance for astronauts when applied in harsh space environments.…”

Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment

“…Specifically, the high-dose local administration may induce serious side effects (e.g., vasculitis, hyperpigmentation, etythema, purpura, burning sensation), and the invasive injection is accompanied with intense pain 15 , 16 . Compared to intralesional injection, microneedles (MNs) have attracted significant interests as a new promising transdermal drug delivery platform, due to nonselective loading capacity, minimal invasiveness, simple operation and good biocompatibility 17 , 18 . Specifically, endogenous stimuli-responsive MNs in response to pathological microenvironment serves as simple and convenient local administration, providing an opportunity for sustainable drug release to enhance the efficacy of drug delivery and minimize the potential side effects 19 , 20 .…”