Recent progress in nanocarrier-based drug delivery systems for antitumour metastasis

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

“…The treatment of various diseases, such as tumors, infections, and degenerative diseases, is inseparable from the development and use of various drugs. [1][2][3][4] The effectiveness of a drug used to treat diseases is affected by factors such as the mode of administration, the rate of dissolution, and the rate of blood clearance, in addition to its composition. [5][6][7][8] In addition, weak drug delivery targeting ability and drug leakage in normal tissues will also reduce the efficacy of drug treatment and increase adverse drug reactions.…”

Co-Assembly of Cancer Drugs with Cyclo-HH Peptides: Insights from Simulations and Experiments

“…Combination therapy through the utilization of nanomaterial-based drug carriers requires additional investigation at both preclinical and clinical levels . Yet, the application of chemotherapy is associated with several challenging aspects, including instability in vivo, development of drug resistance, and adverse side effects due to nonspecific targeting . One emerging solution is the development of nanocarrier systems allowing for encapsulation and target-specific administration of drugs of choice.…”

“…15 Loading of various therapeutic types (from small molecules to proteins 17 ) was demonstrated for the delivery of cancer therapeutics using nanoparticles (i.e., polymeric micelles) in clinical trials. 18,19 Nevertheless, it has been challenging to design nanocarriers for combinations of different cancer drugs, 16 and only a few nanomaterial-based systems are in clinical use. 11 A series of studies reported the computational and experimental design of cancer drug delivery material systems through the use of peptide self-assembly (reviewed in ref 1), some of which emphasized on the importance of cyclization, and metal coordination; cyclization combined with assembly could lead to the formation of particular conformations, promote self-assembly propensity, 20 and therefore facilitate the stabilization of particular assembled states, while metal coordination can lead to enhanced fluorescence (reviewed in ref 1).…”

“…In this context, several considerations, including localization, biodistribution, biocompatibility, and efficacy of nanodrug systems in vivo, in the effort to attain precision cancer diagnosis and therapy, are important to be investigated . Loading of various therapeutic types (from small molecules to proteins) was demonstrated for the delivery of cancer therapeutics using nanoparticles (i.e., polymeric micelles) in clinical trials. , Nevertheless, it has been challenging to design nanocarriers for combinations of different cancer drugs, and only a few nanomaterial-based systems are in clinical use …”

“… 15 Yet, the application of chemotherapy is associated with several challenging aspects, including instability in vivo, development of drug resistance, and adverse side effects due to nonspecific targeting. 16 One emerging solution is the development of nanocarrier systems allowing for encapsulation and target-specific administration of drugs of choice. In this context, several considerations, including localization, biodistribution, biocompatibility, and efficacy of nanodrug systems in vivo, in the effort to attain precision cancer diagnosis and therapy, are important to be investigated.…”