Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

Wang, Ya-Ping; Zhang, Yu; Duan, Xiao-Hui; Mao, Jia-Ji; Pan, Mei; Shen, Jun; Su, Cheng-Yong

doi:10.1016/j.ccr.2023.215570

Cited by 14 publications

(4 citation statements)

References 102 publications

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“…Numerous reviews have provided a comprehensive overview of the design and construction of coordination cages for biological applications [ 20 , 29 , 30 , 31 , 32 ]. At present, some critical reviews on the synthesis and application of MOSCs have been published [ 24 , 25 , 33 ]; however, there is no review exclusively focusing on the bio-applications of MOSCs.…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Fan,

Shi,

Wang

et al. 2024

Molecules

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Coordination cages sustained by metal–ligand interactions feature polyhedral architectures and well-defined hollow structures, which have attracted significant attention in recent years due to a variety of structure-guided promising applications. Sulfonylcalix[4]arenes-based coordination cages, termed metal–organic supercontainers (MOSCs), that possess unique multi-pore architectures containing an endo cavity and multiple exo cavities, are emerging as a new family of coordination cages. The well-defined built-in multiple binding domains of MOSCs allow the efficient encapsulation of guest molecules, especially for drug delivery. Here, we critically discuss the design strategy, and, most importantly, the recent advances in research surrounding cavity-specified host–guest chemistry and biomedical applications of MOSCs.

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Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Fan,

Shi,

Wang

et al. 2024

Molecules

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“…Recently, various controllable methods for preparing stable MOCs with diverse metal centers and outer organic ligands have been developed, laying the foundation for their functional regulation and application explorations. 1−4 Thus, far, MOCs have gained interest in various areas, including catalysis, 5 gas adsorption and separation, 6 biomedicine, 7 and nonlinear optics. 8,9 Recently, considerable efforts have been devoted to promoting the use of MOCs in advanced photolithography, e.g., extremeultraviolet lithography (EUVL; 13.5 nm), state-of-the-art techniques in the semiconductor industry to manufacture sub-5 nm node chips.…”

Section: Introductionmentioning

confidence: 99%

“…They possess tailorable structures at the atomic level. Recently, various controllable methods for preparing stable MOCs with diverse metal centers and outer organic ligands have been developed, laying the foundation for their functional regulation and application explorations. − Thus, far, MOCs have gained interest in various areas, including catalysis, gas adsorption and separation, biomedicine, and nonlinear optics. , Recently, considerable efforts have been devoted to promoting the use of MOCs in advanced photolithography, e.g., extreme-ultraviolet lithography (EUVL; 13.5 nm), state-of-the-art techniques in the semiconductor industry to manufacture sub-5 nm node chips. − The properties of MOCs, including small sizes, well-defined structures, high extreme-ultraviolet (EUV) absorption cross sections, and high reactivity under EUV irradiation, make them promising photoresists for EUVL. − Accordingly, designing and tuning these properties and understanding their fundamental chemistry under EUV irradiation are essential to promote their applications.…”

Section: Introductionmentioning

confidence: 99%

Additive-Assisted Forming High-Quality Thin Films of Sn–Oxo Cluster for Nanopatterning

Zhao,

Huang,

et al. 2024

ACS Appl. Mater. Interfaces

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Recently, metal−oxo clusters (MOCs) have attracted significant interest in fabricating nanoscale patterns in semiconductors via lithography. However, many MOCs are highly crystalline, making it difficult for them to form films and hindering subsequent nanopatterning processes. In this study, we developed a novel and simple method to enhance the filmforming ability of aromatic tetranuclear Sn−oxo clusters by adding additives. Theoretical calculations and Fourier-transform infrared (FTIR) analysis revealed the formation of intermolecular hydrogen bonds between the Sn−oxo clusters and additives, which induced a crystal−gel phase transition at −20 °C, thereby inhibiting the easy crystallization of the Sn− oxo clusters. High-quality and uniform thin films with surface roughness below 0.3 nm were prepared via spin coating. The obtained thin films exhibited good lithographic performance under deep ultraviolet (DUV), electron beam, and extreme-ultraviolet irradiation without a photo acid generator/photoinitiator, and 13-and 21 nm-wide line patterns were obtained on the films via electron-beam and extreme-ultraviolet lithographies. This study will pave the way for the further investigation of novel MOCs for advanced lithography and other thin-film applications.

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“…The past decades have seen tremendous advancements in supramolecular chemistry, especially coordination-driven self-assembly of cage receptors, also known as metal–organic cages/containers (MOCs). − Artificial cage structures possess well-defined shapes, sizes, cavities, and designable functionalities, showing prospects in supramolecular catalysis, − recognition, separation, − reactive compounds stabilization, − biological applications, − molecular machines and devices, − and so on. As an indispensable component of MOCs, metal centers play a crucial role in determining their functionalities and structural diversities.…”

Section: Introductionmentioning

confidence: 99%

Stereochemical Control of Redox Co^II/Co^III-Cages with Switchable Cotton Effects Based on Labile-Static States

Lu,

Wu,

Huang

et al. 2024

J. Am. Chem. Soc.

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The structural dynamics of artificial assemblies, in aspects such as molecular recognition and structural transformation, provide us with a blueprint to achieve bioinspired applications. Here, we describe the assembly of redox-switchable chiral metal− organic cages Λ 8 /Δ 8 -[Pd 6 (Co I I L 3 ) 8 ] 2 8 + and Λ 8 /Δ 8 -[Pd 6 (Co III L 3 ) 8 ] 36+ . These isomeric cages demonstrate an on−off chirality logic gate controlled by their chemical and stereostructural dynamics tunable through redox transitions between the labile Co IIstate and static Co III -state with a distinct Cotton effect. The transition between different states is enabled by a reversible redox process and chiral recognition originating in the tris-chelate Cocenters. All cages in two states are thoroughly characterized by NMR, ESI-MS, CV, CD, and X-ray crystallographic analysis, which clarify their redox-switching behaviors upon chemical reduction/oxidation. The stereochemical lability of the Co II -center endows the Λ 8 /Δ 8 -Co II -cages with efficient chiral-induction by enantiomeric guests, leading to enantiomeric isomerization to switch between Λ 8 /Δ 8 -Co II -cages, which can be stabilized by oxidation to their chemically inert forms of Λ 8 /Δ 8 -Co III -cages. Kinetic studies reveal that the isomerization rate of the Δ 8 -Co III -cage is at least an order of magnitude slower than that of the Δ 8 -Co II -cage even at an elevated temperature, while its activation energy is 16 kcal mol −1 higher than that of the Co II -cage.

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Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

Cited by 14 publications

References 102 publications

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Additive-Assisted Forming High-Quality Thin Films of Sn–Oxo Cluster for Nanopatterning

Stereochemical Control of Redox Co^II/Co^III-Cages with Switchable Cotton Effects Based on Labile-Static States

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Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

Cited by 14 publications

References 102 publications

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal–Organic Supercontainers

Additive-Assisted Forming High-Quality Thin Films of Sn–Oxo Cluster for Nanopatterning

Stereochemical Control of Redox CoII/CoIII-Cages with Switchable Cotton Effects Based on Labile-Static States

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Stereochemical Control of Redox Co^II/Co^III-Cages with Switchable Cotton Effects Based on Labile-Static States