Recent Progress in Fluorescence Signal Design for DNA‐Based Logic Circuits

Yang, Shu; Yang, Chunrong; Song, Lingbo; Chen, Jianchi; Yang, Qianfan

doi:10.1002/chem.201804420

Cited by 12 publications

(7 citation statements)

References 182 publications

(180 reference statements)

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“…Most previous DNA computations designs relied on strand displacement. Whether using toeholds, ,, graphene, − or enzyme catalysis, − the intramolecular energy difference of DNA molecules is very small. Intramolecular energy deficiency is an important obstacle in the promotion of DNA computing.…”

Section: Resultsmentioning

confidence: 99%

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips

Cui

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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DNA logic gates, nanocomputing circuits, have already implemented basic computations and shown great signal potential for nano logic material application. However, the reaction temperature and computing speed still limit its development. Performing complicated computations requires a more stable component and a better computing platform. We proposed a more stable design of logic gates based on a triple, double-stranded, DNA (T-dsDNA) structure. We demonstrated a half adder and a full adder using these DNA nanocircuits and performed the computations in a microfluidic chip device at room temperature. When the solutions were mixed in the device, we obtained the expected results in real time, which suggested that the T-dsDNA combined microfluidic chip provides a concise strategy for large DNA nanocircuits.

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Section: Resultsmentioning

confidence: 99%

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips

Cui

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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“…Following this demonstration that life events can be emulated by synthetic molecular logic research, it is an appropriate point to note that life scientists are joining this field. [71,84,85] DNA strands can act as logic devices, inputs and outputs. These strands act as receptors for complementary strands strictly according to Watson-Crick base pairing.…”

Section: The Field: Molecular Logic 1982: Players Cool Off Beside a B...mentioning

confidence: 99%

A Tool, an App and a Field: Fluorescent PET Sensors, Blood Electrolyte Analysis and Molecular Logic as Products of Supramolecular Photoscience from Northern Ireland and Sri Lanka

Yao

Silva

2022

ChemPlusChem

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The general tool of fluorescent PET (photoinduced electron transfer) sensors/switches -a molecular design principle with engineering features -is outlined, with the aid of frontier orbital energy diagrams. Fluorophores such as anthracene, 1,3diaryl-Δ 2 -pyrazolines and 4-amino-1,8-naphthalimides are employed within this system, alongside receptors such as amines, carboxylates, crown ethers and amino acids. This tool appealed to a multinational corporation for building a medical analyzer for electrolytes such as Na + , K + , Ca 2 + and gases like CO 2 , which became a commercially successful application. Finally, the tool was a springboard for chemistry to cross into computer science. The field of molecular logic can elucidate how molecules inside us handle information. Molecular examples of the simplest logic gates such as YES, NOT, OR, AND are described. A case of a human-level computation -visual edge detection -is also included.

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“…Comparing this to silicon-based computation, although many challenges in designing computation devices, aptamer-based hydrogels logic circuits are still developing with great rapidity, due to their stability, biocompatibility, and predictable structure (143)(144)(145)(146). Yin et al (147) exploited a hydrogel structure based on hybridization behavior between crosslinker strands with aptamer sequences of ATP and cocaine molecules onto polymer chains.…”

Section: Aptamer-based Hydrogels For Logic Devicesmentioning

confidence: 99%

Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels

Wang

et al. 2020

Front. Med.

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Aptamers are special types of single-stranded DNA generated by a process called systematic evolution of ligands by exponential enrichment (SELEX). Due to significant advances in the chemical synthesis and biotechnological production, aptamers have gained considerable attention as versatile building blocks for the next generation of soft materials. Hydrogels are high water-retainable materials with a three-dimensional (3D) polymeric network. Aptamers, as a vital element, have greatly expanded the applications of hydrogels. Due to their biocompatibility, selective binding, and molecular recognition, aptamer-based hydrogels can be utilized for bioanalytical and biomedical applications. In this review, we focus on the latest strategies of aptamer-based hydrogels in bioanalytical and biomedical applications. We begin this review with an overview of the underlying design principles for the construction of aptamer-based hydrogels. Next, we will discuss some bioanalytical and biomedical applications of aptamer-based hydrogel including biosensing, target capture and release, logic devices, gene and cancer therapy. Finally, the recent progress of aptamer-based hydrogels is discussed, along with challenges and future perspectives.

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Recent Progress in Fluorescence Signal Design for DNA‐Based Logic Circuits

Cited by 12 publications

References 182 publications

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips

A Tool, an App and a Field: Fluorescent PET Sensors, Blood Electrolyte Analysis and Molecular Logic as Products of Supramolecular Photoscience from Northern Ireland and Sri Lanka

Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels

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