Recent progress in development and chemical modification of poly(hydroxybutyrate)-based blends for potential medical applications

Raza, Zulfiqar Ali; Khalil, Shanza; Abid, Sharjeel

doi:10.1016/j.ijbiomac.2020.05.114

Cited by 70 publications

(52 citation statements)

References 165 publications

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“…P(3HB) does not crystallize to form an ordered structure, it is difficult to process P(3HB) into products, which demonstrate low shock resistance and rigidity and are prone to "physical ageing" [40,41]. P(3HB)-based products are degraded slowly, and implants may cause pronounced foreign body reaction [42,43]. Properties of polymeric materials, including P(3HB), can be improved by using biological, chemical, and physical methods, such as fabrication of P(3HB) composites with other materials, biosynthesis of PHA copolymers, chemical modification, and physical treatment of the surface of polymer products [6,25,27,[44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

et al. 2021

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The study reports results of using a CO2-laser in continuous wave (3 W; 2 m/s) and quasi-pulsed (13.5 W; 1 m/s) modes to treat films prepared by solvent casting technique from four types of polyhydroxyalkanoates (PHAs), namely poly-3-hydroxybutyrate and three copolymers of 3-hydroxybutyrate: with 4-hydroxybutyrate, 3-hydroxyvalerate, and 3-hydroxyhexanoate (each second monomer constituting about 30 mol.%). The PHAs differed in their thermal and molecular weight properties and degree of crystallinity. Pristine films differed in porosity, hydrophilicity, and roughness parameters. The two modes of laser treatment altered these parameters and biocompatibility in diverse ways. Films of P(3HB) had water contact angle and surface energy of 92° and 30.8 mN/m, respectively, and average roughness of 144 nm. The water contact angle of copolymer films decreased to 80–56° and surface energy and roughness increased to 41–57 mN/m and 172–290 nm, respectively. Treatment in either mode resulted in different modifications of the films, depending on their composition and irradiation mode. Laser-treated P(3HB) films exhibited a decrease in water contact angle, which was more considerable after the treatment in the quasi-pulsed mode. Roughness parameters were changed by the treatment in both modes. Continuous wave line-by-line irradiation caused formation of sintered grooves on the film surface, which exhibited some change in water contact angle (76–80°) and reduced roughness parameters (to 40–45 mN/m) for most films. Treatment in the quasi-pulsed raster mode resulted in the formation of pits with no pronounced sintered regions on the film surface, a more considerably decreased water contact angle (to 67–76°), and increased roughness of most specimens. Colorimetric assay for assessing cell metabolic activity (MTT) in NIH 3T3 mouse fibroblast culture showed that the number of fibroblasts on the films treated in the continuous wave mode was somewhat lower; treatment in quasi-pulsed radiation mode caused an increase in the number of viable cells by a factor of 1.26 to 1.76, depending on PHA composition. This is an important result, offering an opportunity of targeted surface modification of PHA products aimed at preventing or facilitating cell attachment.

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Section: Introductionmentioning

confidence: 99%

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

et al. 2021

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“…Regardless of their economic promise, most PHA-based biomaterials are highly hydrophobic, have a low heat distortion temperature, and have poor gas barrier properties, particularly crystalline short chain length PHA with greater monomeric compositions of 3-hydroxybutyric acid such as poly hydroxybutyrate (PHB). As a result of these limitations, they degrade slowly (Raza et al 2020 ). When compared to other bioplastics, the cost of producing PHA is much higher.…”

Section: An Account Of Pha: Promising Biodegradable Plasticsmentioning

confidence: 99%

Plastic accumulation during COVID-19: call for another pandemic; bioplastic a step towards this challenge?

Mittal

Aggarwal

2022

Environ Sci Pollut Res

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Plastic pollution has become a serious transboundary challenge to nature and human health, with estimation of reports published — predicting a twofold increase in plastic waste by 2030. However, due to the COVID-19 pandemic, the excessive use of single-use plastics (including face masks, gloves and personal protective equipment) would possibly exacerbate such forecasts. The transition towards eco-friendly alternatives like bio-based plastics and new emerging sustainable technologies would be vital to deal with future pandemics, even though the use or consumption of plastics has greatly enhanced our quality of life; it is however critical to move towards bioplastics. We cannot deny the fact that bioplastics have some challenges and shortcomings, but still, it is an ideal option for opt. The circular economy is the need of the hour for waste management. Along with all these practices, individual accountability, corporate intervention and government policy are also needed to prevent us from moving from one crisis to the next. Only through cumulative efforts, we will be able to cope up with this problem. This article collected scattered information and data about accumulation of plastic during COVID-19 worldwide. Additionally, this paper illustrates the substitution of petroleum-based plastics with bio-based plastics. Different aspects are discussed, ranging from advantages to challenges in the way of bioplastics.

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“…PHB has a promising industrial interest due to its biodegradable, elastomeric, thermoplastic, biodegradable, biocompatible, and immunological properties [10,11]. In addition, PHB can be used in the manufacture of plastics for quick and routine use, e.g., bags for the management and reduction of domestic and industrial waste, biosensors, tissue engineering scaffolds, drug carriers for various medical treatments used as biomaterials, and others [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Biotechnological Potential of Intracellular Polyhydroxybutyrate by Stigeoclonium sp. B23 Using Cassava Peel as Carbon Source

et al. 2021

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The possibility of utilizing lignocellulosic agro-industrial waste products such as cassava peel hydrolysate (CPH) as carbon sources for polyhydroxybutyrate (PHB) biosynthesis and characterization by Amazonian microalga Stigeoclonium sp. B23. was investigated. Cassava peel was hydrolyzed to reducing sugars to obtain increased glucose content with 2.56 ± 0.07 mmol/L. Prior to obtaining PHB, Stigeoclonium sp. B23 was grown in BG-11 for characterization and Z8 media for evaluation of PHB nanoparticles’ cytotoxicity in zebrafish embryos. As results, microalga produced the highest amount of dry weight of PHB with 12.16 ± 1.28 (%) in modified Z8 medium, and PHB nanoparticles exerted some toxicity on zebrafish embryos at concentrations of 6.25–100 µg/mL, increased mortality (<35%) and lethality indicators as lack of somite formation (<25%), non-detachment of tail, and lack of heartbeat (both <15%). Characterization of PHB by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC), and thermogravimetry (TGA) analysis revealed the polymer obtained from CPH cultivation to be morphologically, thermally, physically, and biologically acceptable and promising for its use as a biomaterial and confirmed the structure of the polymer as PHB. The findings revealed that microalgal PHB from Stigeoclonium sp. B23 was a promising and biologically feasible new option with high commercial value, potential for biomaterial applications, and also suggested the use of cassava peel as an alternative renewable resource of carbon for PHB biosynthesis and the non-use of agro-industrial waste and dumping concerns.

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Recent progress in development and chemical modification of poly(hydroxybutyrate)-based blends for potential medical applications

Cited by 70 publications

References 165 publications

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

Plastic accumulation during COVID-19: call for another pandemic; bioplastic a step towards this challenge?

Characterization and Biotechnological Potential of Intracellular Polyhydroxybutyrate by Stigeoclonium sp. B23 Using Cassava Peel as Carbon Source

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