Recent Progress in Cardiovascular Research Involving Single-Cell Omics Approaches

Abstract

Cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Although the spectrum of the heart from development to disease has long been studied, it remains largely enigmatic. The emergence of single-cell omics technologies has provided a powerful toolbox for defining cell heterogeneity, unraveling previously unknown pathways, and revealing intercellular communications, thereby boosting biomedical research and obtaining numerous novel findings over the last 7 years. Not only cell atlases of normal and developing hearts that provided substantial research resources, but also some important findings regarding cell-type-specific disease gene program, could never have been established without single-cell omics technologies. Herein, we briefly describe the latest technological advances in single-cell omics and summarize the major findings achieved by such approaches, with a focus on development and homeostasis of the heart, myocardial infarction, and heart failure.

The molecular mechanism of Ligusticum wallichii for improving idiopathic pulmonary fibrosis

“…In recent 10 years, with the development of modern genomics, [1][2][3] proteomics, [4,5] metabolomics, [6,7] and other "omics" theory [8,9] and with the introduction of system biology perspective and the application of bio informatics, the concept of network Pharmacology came into being. [10,11] It revealed the mystery of the synergistic effect of multi molecular drugs on the human body [12] based on the "disease-gene-targetdrug" interaction network and it systematically and comprehensively observed the intervention and influence of drugs on the disease network through network analysis.…”