Recent progress in biomedical applications of titanium dioxide

Yin, Zi; Wu, Long; Yang, Hua Gui; Su, Yong Hua

doi:10.1039/c3cp43938k

Cited by 429 publications

(138 citation statements)

References 129 publications

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“…Titanium oxide (TiO 2 ) has a wide range of biomedical applications (Fei Yin et al 2013). For instance, in bone-substituting materials, the biofluid first makes contact with a thin TiO 2 layer that spontaneously emerges on the top surface of metallic titanium (Hanawa 2011;Feng et al 2003).…”

Section: Biomedical Applications Of Metal Oxide Nanoparticlesmentioning

confidence: 99%

Biomedical applications of nanotechnology

et al. 2017

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The ability to investigate substances at the molecular level has boosted the search for materials with outstanding properties for use in medicine. The application of these novel materials has generated the new research field of nanobiotechnology, which plays a central role in disease diagnosis, drug design and delivery, and implants. In this review, we provide an overview of the use of metallic and metal oxide nanoparticles, carbon-nanotubes, liposomes, and nanopatterned flat surfaces for specific biomedical applications. The chemical and physical properties of the surface of these materials allow their use in diagnosis, biosensing and bioimaging devices, drug delivery systems, and bone substitute implants. The toxicology of these particles is also discussed in the light of a new field referred to as nanotoxicology that studies the surface effects emerging from nanostructured materials.

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Section: Biomedical Applications Of Metal Oxide Nanoparticlesmentioning

confidence: 99%

Biomedical applications of nanotechnology

et al. 2017

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“…In this line, nano-particles, such as metallic NPs, ceramic NPs, and quantum dots could help improve PDT of cancer (7). In particular, experimental results showed that TiO 2 NPs could be an excellent PS in PDT of cancer due to their unique properties, such as strong optical absorption, high chemical stability, and non-toxicity (8,9). Low concentrations of TiO 2 NPs did not show significant toxicity by themselves yet, irradiation of these NPs by ultraviolet (UV) light could lead to generation of ROS and consequently cell death.…”

Section: Introductionmentioning

confidence: 99%

GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

et al. 2016

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Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1 -100 µg/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential for further evaluation as new generation of PSs for cancer therapy.

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“…Nanoparticles (NPs) are used ubiquitously in food, medicine, military, construction, cosmetics and sports [2]. Titanium dioxide NPs (TDNPs), in particular, are considered vital in the development of antimicrobiotic applications [3,4]. However, there are increasing concerns that nanotechnology may threaten our health [1].…”

Section: Introductionmentioning

confidence: 99%

“…Anatase TDNPs are common NPs being used for many purposes such as antibacterial effects, sunscreens and cosmetics, making use of their photodynamic properties [4]. The toxic potential of TDNPs is unclear in the presence and absence of ultraviolet (UV) irradiation.…”

Section: Introductionmentioning

confidence: 99%

Cancer Therapeutic Effects of Titanium Dioxide Nanoparticles Are Associated with Oxidative Stress and Cytokine Induction

et al. 2015

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Nanoparticles (NPs) are considered to influence the inflammatory process; however, the precise mechanism and the significance in tumors are still not clear. In this study, when CT26 and LL2 mouse cancer cells were treated with 6-nm anatase titanium dioxide NPs (TDNPs) without ultraviolet irradiation, oxidative stress and induction of inflammatory cytokines were observed. Oxidative stress was further increased by disease-associated conditions such as high glucose concentrations and hypoxia. Inhaled or orally administered TDNPs generated granulomatous lesions in the lungs and colon of the rodent models tested, with increased oxidative stress and inflammatory cytokines. Oxidative stress and inflammatory cytokines were also found in cancer cells treated with gold or carbon black NPs. Treatment of CT26 cells with 10- to 70-nm rutile TDNPs showed that smaller NPs produced more oxidative stress and inflammatory cytokines than larger ones did. To avoid diffusion of TDNPs and to minimize toxicity, 10-nm TDNPs were suspended in a collagen gel inserted into a subcutaneous tumor in a CT26 mouse. A single TDNP treatment via this method inhibited tumor growth in a size- and dose-dependent manner, and resulted in lower levels of urinary 8-OHdG when compared to systemically administered TDNPs. These findings suggest that TDNPs might be useful for the local treatment of tumors.

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Recent progress in biomedical applications of titanium dioxide

Cited by 429 publications

References 129 publications

Biomedical applications of nanotechnology

Biomedical applications of nanotechnology

GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

Cancer Therapeutic Effects of Titanium Dioxide Nanoparticles Are Associated with Oxidative Stress and Cytokine Induction

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