Recent progress in alginate-based carriers for ocular targeting of therapeutics

Karmakar, Srinibas; Manna, Sreejan; Kabiraj, Sourav; Jana, Sougata

doi:10.1016/j.fhfh.2022.100071

Cited by 22 publications

(13 citation statements)

References 99 publications

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“…Alginate is an anionic polymer that is present on the cell walls of brown algae. Some bacteria can also produce alginate, but commercial alginate is extracted from algae biomass [ 73 , 74 , 75 ]. Alginate has an unbranched chain consisting of 1,4-β-D-mannuronic and 1,4 α-L-guluronic acids, whose carboxylate groups carry a net negative charge.…”

Section: Biopolymeric Matrices As Carriers For Pgpbmentioning

confidence: 99%

“…The main characteristic of alginate is gelation in contact with calcium ions (Ca 2+ ), resulting in hydrogels with an ionic crosslinked three-dimensional matrix, which generally are obtained as beads, capsules, micro- and nanocapsules [ 14 , 16 , 76 ]. Alginates are biodegradable, and the presence of reactive carboxylic groups and their status as GRAS (Generally Recognized as Safe) by the FDA (Food and Drug Administration-USA) make them ideal candidates to be used as carriers for PGPB [ 73 , 74 ]. Alginates are extensively studied as PGPB carriers [ 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ] to be used as biofertilizers or biopesticides.…”

Section: Biopolymeric Matrices As Carriers For Pgpbmentioning

confidence: 99%

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Perspectives on the Use of Biopolymeric Matrices as Carriers for Plant-Growth Promoting Bacteria in Agricultural Systems

et al. 2023

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The subject of this review is to discuss some aspects related to the use of biopolymeric matrices as carriers for plant-growth promoting bacteria (PGPB) in agricultural systems as a possible technological solution for the establishment of agricultural production practices that result in fewer adverse impacts on the environment, reporting some promising and interesting results on the topic. Results from the encapsulation of different PGPB on alginate, starch, chitosan, and gelatin matrices are discussed, systematizing some advances made in this area of knowledge in recent years. Encapsulation of these bacteria has been shown to be an effective method for protecting them from unsuitable environments, and these new products that can act as biofertilizers and biopesticides play an important role in the establishment of a sustainable and modern agriculture. These new products are technological solutions for replacing deleterious chemical fertilizers and pesticides, maintaining soil fertility and stability, and improving crop productivity and food security. Finally, in the near future, scale-up studies will have to provide new information about the large-scale production of these materials as well as their application in the field under different biotic and abiotic stress conditions.

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Section: Biopolymeric Matrices As Carriers For Pgpbmentioning

confidence: 99%

Section: Biopolymeric Matrices As Carriers For Pgpbmentioning

confidence: 99%

Perspectives on the Use of Biopolymeric Matrices as Carriers for Plant-Growth Promoting Bacteria in Agricultural Systems

et al. 2023

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“…Furthermore, biocompatibility and biodegradability are some of the physiological properties that make it suitable for use as films and gels developed for medical and food applications [74]. Alginic acid has a biodegradable and biocompatible nature that is favorable for researchers; therefore, its use has been encouraged in ocular treatments [75]. Ocular delivery therapeutics are a current trend in ophthalmology, and alginates have been employed to play an imperative role because of their biocompatibility and immunogenicity [76].…”

Section: Alginic Acidmentioning

confidence: 99%

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Akulo¹,

Adalı

Moyo³

et al. 2022

Polymers

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Glaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as rapid nasolacrimal drainage. Poor intraocular penetration and frequent administration may also cause ocular cytotoxicity. A novel approach to overcome these drawbacks is the use of injectable hydrogels administered intravitreously for sustained drug delivery to the target site. These injectable hydrogels are used as nanocarriers to intimately interact with specific diseased ocular tissues to increase the therapeutic efficacy and drug bioavailability of the anti-glaucomic drugs. The human eye is very delicate, and is sensitive to contact with any foreign body material. However, natural biopolymers are non-reactive, biocompatible, biodegradable, and lack immunogenic and inflammatory responses to the host whenever they are incorporated in drug delivery systems. These favorable biomaterial properties have made them widely applicable in biomedical applications, with minimal adversity. This review highlights the importance of using natural biopolymer-based intravitreal hydrogel drug delivery systems for glaucoma treatment over conventional methods.

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“…ALG hydrogels are highly biocompatible and have a low interaction with cells as they lack adhesion sequences [ 1 , 2 ], which is the reason why alginate hydrogels have been proposed for in vitro and in vivo applications, especially for drug delivery [ 3 ], 3D cell culture [ 4 , 5 ] and bioprinting [ 2 , 6 ]. On the other hand, industrial processes for the extraction of alginate from brown algae or its biotechnological production using certain bacteria make high-purity alginates available for medical applications [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

et al. 2022

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Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also has a drawback in that its structure is not very stable in a culture medium with cellular activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell proliferation in the culture was tested in a bioreactor under gentle agitation.

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Recent progress in alginate-based carriers for ocular targeting of therapeutics

Cited by 22 publications

References 99 publications

Perspectives on the Use of Biopolymeric Matrices as Carriers for Plant-Growth Promoting Bacteria in Agricultural Systems

Perspectives on the Use of Biopolymeric Matrices as Carriers for Plant-Growth Promoting Bacteria in Agricultural Systems

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

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