Recent progress and future plans of heavy-ion cancer radiotherapy with HIMAC

Noda, K.; Furukawa, Takuji; Fujimoto, T.; Hara, Yusuke; Inaniwa, Taku; Iwata, Y.; Katagiri, Ken; Kanematsu, Nobuyuki; Mizushima, Kota; Mori, Shinichiro; Sakamoto, Naoya; Saraya, Y.; Sato, Shinji; Shirai, Tomoyuki; Takada, Mamoru; Takei, Yasuhiko; Tansyo, R.; Yonai, Shunsuke

doi:10.1016/j.nimb.2017.04.021

Cited by 16 publications

(17 citation statements)

References 26 publications

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“…The main goal is to increase the dose rate at the patient and minimise the treatment time, of course keeping utmost attention to beam quality and safety. Another key development will be represented by the implementation of a multi-energy-extraction within a single spill [50], since this is going to exploit at best the beam intensity, reduce the beam losses and consequently minimise the radioprotection impact and above all shorten the patient treatment duration.…”

Section: Ocular Treatments: a Novel Approachmentioning

confidence: 99%

The National Centre for Oncological Hadrontherapy (CNAO): Status and perspectives

Rossi

2015

Physica Medica

109

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Section: Ocular Treatments: a Novel Approachmentioning

confidence: 99%

The National Centre for Oncological Hadrontherapy (CNAO): Status and perspectives

Rossi

2015

Physica Medica

109

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“…As several strategies of unknown quality that aim to achieve this exist, it will be important to carefully consider the advantages and disadvantages of each planning strategy and for a given tumor. Some of these questions are currently being addressed and most noteworthy, NIRS in Japan has started a research initiative to utilize their spot‐scanning and heavy ion rotating gantry to employ LET‐painting for treating tumor hypoxia …”

Section: Rbe Modeling Concept/importance Of Let and Let/rbe‐optimizmentioning

confidence: 99%

“…Thus, if we can understand the biological effects and response to each radiation type, we may treat complicated and radioresistant tumors with optimized multi‐ion therapy. First biological experiments may commence soon: NIRS in Japan has recently announced that they have started a comprehensive research initiative where they will investigate the potential of multi‐ion therapy at the HIMAC facility, partially described in . In vivo experiments are planned to investigate whether the alleged therapeutic benefit can be confirmed.…”

Section: Beyond Protons and Carbon Ionsmentioning

confidence: 99%

“…Some of these questions are currently being addressed and most noteworthy, NIRS in Japan has started a research initiative to utilize their spot-scanning and heavy ion rotating gantry to employ LETpainting for treating tumor hypoxia. 85,86 FIG. 7.…”

Section: A Dose Weighted Let-optimization Let-paintingmentioning

confidence: 99%

“…First biological experiments may commence soon: NIRS in Japan has recently announced that they have started a comprehensive research initiative where they will investigate the potential of multi-ion therapy at the HIMAC facility, partially described in. 85,86 In vivo experiments are planned to investigate whether the alleged therapeutic benefit can be confirmed. Thus, we are on the way to a multimodal future.…”

Section: Beyond Protons and Carbon Ionsmentioning

confidence: 99%

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Computational models and tools

Schuemann

Bassler

Inaniwa³

2018

Medical Physics

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In this chapter, we describe two different methods, analytical (pencil beam) algorithms and Monte Carlo simulations, used to obtain the intended dose distributions in patients and evaluate their strengths and shortcomings. We discuss the difference between the prescribed physical dose and the biologically effective dose, the relative biological effectiveness (RBE) between ions and photons and the dependence of RBE on the linear energy transfer (LET). Lastly, we show how LET‐ or RBE‐based optimization can be used to improve treatment plans and explore how the availability of multimodality ion beam facilities can be used to design a tumor‐specific optimal treatment.

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The rationale for a carbon ion radiation therapy facility in Australia

Thwaites,

Prokopovich,

Garrett

et al. 2023

J of Medical Radiation Sci

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Australia has taken a collaborative nationally networked approach to achieve particle therapy capability. This supports the under‐construction proton therapy facility in Adelaide, other potential proton centres and an under‐evaluation proposal for a hybrid carbon ion and proton centre in western Sydney. A wide‐ranging overview is presented of the rationale for carbon ion radiation therapy, applying observations to the case for an Australian facility and to the clinical and research potential from such a national centre.

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Recent progress and future plans of heavy-ion cancer radiotherapy with HIMAC

Cited by 16 publications

References 26 publications

The National Centre for Oncological Hadrontherapy (CNAO): Status and perspectives

The National Centre for Oncological Hadrontherapy (CNAO): Status and perspectives

Computational models and tools

The rationale for a carbon ion radiation therapy facility in Australia

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