Recent pharmacological advances in the repurposing of artemisinin drugs

Meng, Yuqing; Lyu, Haining; Wong, Yin Kwan; Zhang, Xing; Zhu, Yongping; Gao, Peng; Sun, Peng; Song, Yali; Lin, Lizhu; Wang, Jigang

doi:10.1002/med.21837

Cited by 28 publications

(13 citation statements)

References 202 publications

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“…Since the 2015 Nobel Prize in Physiology or Medicine was awarded to Chinese scientists, Artemisia has gained global attention (Efferth et al, 2015). Artemisia and its derivatives are used to treat malaria and are widely used to treat various oncological and cardiovascular diseases (Ahmad et al, 2015;Efferth, 2017;Lang et al, 2019;Feng et al, 2020;Jiang et al, 2020;Yin et al, 2020;Meng et al, 2021). As the COVID-19 epidemic rages around the world, some studies have been conducted to fully elucidate the mechanisms behind A. annua's treatment of COVID-19 through network pharmacology and molecular docking techniques (Tang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Jia

Jing²,

Wang³

et al. 2022

Front. Physiol.

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Background: Abdominal aortic aneurysm (AAA) is a degenerative disease that causes health problems in humans. However, there are no effective drugs for the treatment of AAA. Artemisia annua L. (A. annua) is a traditional herbal that has been widely used in cardiovascular disease. Based on network pharmacology and molecular docking technology, this study predicted the practical components and potential mechanisms of A. annua inhibiting the occurrence and development of AAA.Methods: The main active ingredients and targets of A. annua were screened through the TCMSP database; the GeneCards, OMIM, PharmGkb, and TTD databases were used to search for the targeted genes of AAA and map them to the targets of the active ingredients to obtain the active ingredient therapy of A. annua. The targets of AAA were to construct a protein interaction network through the STRING platform. R software was used to carry out the enrichment analysis of GO and KEGG for relevant targets, and Cytoscape was used to construct the active ingredient-target network prediction model of A. annua. Finally, AutoDock Vina was used to verify the results of the active ingredients and critical targets.Results: The main active ingredients obtained from A. annua for the treatment of AAA include quercetin, luteolin, kaempferol, isorhamnetin, and artemetin, as well as 117 effective targets, including RELA, MAPK14, CCND1, MAPK1, AKT1, MYC, MAPK8, TP53, ESR1, FOS, and JUN. The 11 targeted genes might play a key role in disease treatment. Enriched in 2115 GO biological processes, 159 molecular functions, 56 cellular components, and 156 KEGG pathways, inferred that its mechanism of action might be related to PI3K-Akt signaling pathway, fluid shear stress, atherosclerosis, and AGE-RAGE signaling pathway. Molecular docking results showed that the top five active components of A. annua had a good affinity for core disease targets and played a central role in treating AAA. The low binding energy molecular docking results provided valuable information for the development of drugs to treat AAA.Conclusion: Therefore, A. annua may have multiple components, multiple targets, and multiple signaling pathways to play a role in treating AAA. A. annua may have the potential to treat AAA.

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Section: Discussionmentioning

confidence: 99%

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Jia

Jing²,

Wang³

et al. 2022

Front. Physiol.

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“…Artemisinin, a sesquiterpene lactone isolated from Artemisia annua L. with outstanding antimalarial effect, has been regarded as the most effective and impactful antimalarial drug ( Paddon et al, 2013 ). Except for its antimalarial effect, ART has exhibited effects on antioxidant, anti-inflammation, anti-fibrotic, and anti-tumor ( Dolivo et al, 2021 ; Meng et al, 2021 ). Bai et al conducted a study investigating whether Artemisinin could regulate inflammation factors by mediating exosome release in vivo ( Bai et al, 2019 ).…”

Section: Exosomes Modulators From Compounds Isolated From Tcmmentioning

confidence: 99%

Exosomes: A novel insight into traditional Chinese medicine

Zhao

Liang

et al. 2022

Front. Pharmacol.

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Exosomes are small extracellular vesicles and play an essential role in the mediation of intercellular communication both in health and disease. Traditional Chinese medicine (TCM) has historically been used to maintain human health and treat various diseases up till today. The interplay between exosomes and TCM has attracted researchers’ growing attention. By integrating the available evidence, TCM formulas and compounds isolated from TCM as exosome modulators have beneficial effects on multiple disorders, such as tumors, kidney diseases, and hepatic disease, which may associate with inhibiting cells proliferation, anti-inflammation, anti-oxidation, and attenuating fibrosis. Exosomes, a natural delivery system, are essential in delivering compounds isolated from TCM to target cells or tissues. Moreover, exosomes may be the potential biomarkers for TCM syndromes, providing strategies for TCM treatment. These findings may provide a novel insight into TCM from exosomes and serve as evidence for better understanding and development of TCM.

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“…It is well known that artemisinins are cheap and have rapid activity, high potency, and minimal toxicity, but a short half-life, which makes artemisinins a candidate drug that maximizes the advantages of drug reuse [17]. Many studies have emphasized the potential of artemisinins as a novel antidiabetic agent.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect and Possible Mechanisms of Artemisinin and Its Derivatives for Diabetic Nephropathy: A Systematic Review and Meta-Analysis in Animal Models

Feng

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Artemisinin and its derivatives have potential antidiabetic effects. There is no evaluation of reported studies in the literature on the treatment of diabetic nephropathy (DN), one of the commonest diabetic microangiopathies, with artemisinins. Here, we aimed to evaluate preclinical evidence for the efficacy and possible mechanisms of artemisinins in reducing diabetic renal injury. Methods. We conducted an electronic literature search in fourteen databases from their inception to November 2021. All animal studies assessing the efficacy and safety of artemisinins in DN were included, regardless of publication or language. Overall, 178 articles were screened according to predefined inclusion and exclusion criteria. Finally, 18 eligible articles were included in this systematic review. The SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) risk-of-bias tool was used to assess the risk of bias in the included studies. The primary outcomes were kidney function, proteinuria, and renal pathology. Secondary endpoints included changes in fasting plasma glucose (FPG) levels, body weight, and relevant mechanisms. Results. Of the 18 included articles involving 418 animal models of DN, 1, 2, 6, and 9 used dihydroartemisinin, artemether, artesunate, and artemisinin, respectively. Overall, artemisinins reduced indicators of renal function, including blood urea nitrogen ( P < 0.00001 ), serum creatinine ( P < 0.00001 ), and kidney index ( P = 0.0001 ) compared with control group treatment. Measurements of proteinuria ( P < 0.00001 ), microalbuminuria ( P < 0.05 ), and protein excretion ( P = 0.0002 ) suggested that treatment with artemisinins reduced protein loss in animals with DN. Artemisinins may lower blood glucose levels ( P = 0.01 ), but there is a risk of weight gain ( P < 0.00001 ). Possible mechanisms of action of artemisinins include delaying renal fibrosis, reducing oxidative stress, and exerting antiapoptotic and anti-inflammatory effects. Conclusion. Available evidence suggests that artemisinins may be protective against renal injury secondary to diabetes in preclinical studies; however, high-quality and long-term trials are needed to reliably determine the balance of benefits and harms.

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Recent pharmacological advances in the repurposing of artemisinin drugs

Cited by 28 publications

References 202 publications

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Exosomes: A novel insight into traditional Chinese medicine

Protective Effect and Possible Mechanisms of Artemisinin and Its Derivatives for Diabetic Nephropathy: A Systematic Review and Meta-Analysis in Animal Models

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